Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

Dennis Sandris Nielsen; Lukasz Krych; Karsten Buschard; Camilla Hartmann Friis Hansen; Axel Jacob Kornerup Hansen

doi:10.1016/j.febslet.2014.04.010

Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

Dennis Sandris Nielsen, Lukasz Krych, Karsten Buschard, Camilla Hartmann Friis Hansen, Axel Jacob Kornerup Hansen

Food Microbiology, Gut Health, and Fermentation

55 Citations (Scopus)

1539 Downloads (Pure)

Abstract

Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.

Original language	English
Journal	FEBS Letters
Volume	588
Issue number	22
Pages (from-to)	4234-4243
Number of pages	10
ISSN	0014-5793
DOIs	https://doi.org/10.1016/j.febslet.2014.04.010
Publication status	Published - 17 Nov 2014

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title = "Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes",

abstract = "Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.",

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AU - Nielsen, Dennis Sandris

AU - Krych, Lukasz

AU - Buschard, Karsten

AU - Hansen, Camilla Hartmann Friis

AU - Hansen, Axel Jacob Kornerup

PY - 2014/11/17

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N2 - Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.

AB - Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.

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Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

Abstract

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