A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

C S Rose; N Grarup; N T Krarup; P Poulsen; L Wegner; Trine Nielsen; K Banasik; K Faerch; G Andersen; A Albrechtsen; K Borch-Johnsen; J O Clausen; T Jørgensen; A Vaag; O Pedersen; T Hansen

doi:10.1007/s00125-009-1463-z

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

C S Rose, N Grarup, N T Krarup, P Poulsen, L Wegner, Trine Nielsen, K Banasik, K Faerch, G Andersen, A Albrechtsen, K Borch-Johnsen, J O Clausen, T Jørgensen, A Vaag, O Pedersen, T Hansen

22 Citationer (Scopus)

Abstract

An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported. In Danes we aimed to examine rs560887 in relation to plasma glucose and serum insulin responses following oral and i.v. glucose loads and in relation to hepatic glucose production during a hyperinsulinaemic-euglycaemic clamp. Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	52
Udgave nummer	10
Sider (fra-til)	2122-2129
Antal sider	8
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-009-1463-z
Status	Udgivet - 2009

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10.1007/s00125-009-1463-z

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Rose, C. S., Grarup, N., Krarup, N. T., Poulsen, P., Wegner, L., Nielsen, T., Banasik, K., Faerch, K., Andersen, G., Albrechtsen, A., Borch-Johnsen, K., Clausen, J. O., Jørgensen, T., Vaag, A., Pedersen, O., & Hansen, T. (2009). A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads. Diabetologia, 52(10), 2122-2129. https://doi.org/10.1007/s00125-009-1463-z

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads. / Rose, C S; Grarup, N; Krarup, N T et al.

I: Diabetologia, Bind 52, Nr. 10, 2009, s. 2122-2129.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Rose, CS, Grarup, N, Krarup, NT, Poulsen, P, Wegner, L, Nielsen, T , Banasik, K , Faerch, K, Andersen, G, Albrechtsen, A, Borch-Johnsen, K, Clausen, JO, Jørgensen, T, Vaag, A , Pedersen, O & Hansen, T 2009, 'A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads', Diabetologia, bind 52, nr. 10, s. 2122-2129. https://doi.org/10.1007/s00125-009-1463-z

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title = "A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads",

abstract = "An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported. In Danes we aimed to examine rs560887 in relation to plasma glucose and serum insulin responses following oral and i.v. glucose loads and in relation to hepatic glucose production during a hyperinsulinaemic-euglycaemic clamp. Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.",

keywords = "ATP-Binding Cassette Transporters, Adult, Blood Glucose, Fasting, Female, Genotype, Glucose, Glucose Tolerance Test, Glucose-6-Phosphatase, Humans, Insulin, Liver, Male, Middle Aged",

author = "Rose, {C S} and N Grarup and Krarup, {N T} and P Poulsen and L Wegner and Trine Nielsen and K Banasik and K Faerch and G Andersen and A Albrechtsen and K Borch-Johnsen and Clausen, {J O} and T J{\o}rgensen and A Vaag and O Pedersen and T Hansen",

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doi = "10.1007/s00125-009-1463-z",

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T1 - A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

AU - Rose, C S

AU - Grarup, N

AU - Krarup, N T

AU - Poulsen, P

AU - Wegner, L

AU - Nielsen, Trine

AU - Banasik, K

AU - Faerch, K

AU - Andersen, G

AU - Albrechtsen, A

AU - Borch-Johnsen, K

AU - Clausen, J O

AU - Jørgensen, T

AU - Vaag, A

AU - Pedersen, O

AU - Hansen, T

N1 - Export Date: 4 November 2009Source: Scopus

PY - 2009

Y1 - 2009

N2 - An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported. In Danes we aimed to examine rs560887 in relation to plasma glucose and serum insulin responses following oral and i.v. glucose loads and in relation to hepatic glucose production during a hyperinsulinaemic-euglycaemic clamp. Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.

AB - An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported. In Danes we aimed to examine rs560887 in relation to plasma glucose and serum insulin responses following oral and i.v. glucose loads and in relation to hepatic glucose production during a hyperinsulinaemic-euglycaemic clamp. Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.

KW - ATP-Binding Cassette Transporters

KW - Adult

KW - Blood Glucose

KW - Fasting

KW - Female

KW - Genotype

KW - Glucose

KW - Glucose Tolerance Test

KW - Glucose-6-Phosphatase

KW - Humans

KW - Insulin

KW - Liver

KW - Male

KW - Middle Aged

U2 - 10.1007/s00125-009-1463-z

DO - 10.1007/s00125-009-1463-z

M3 - Journal article

C2 - 19669124

SN - 0012-186X

VL - 52

SP - 2122

EP - 2129

JO - Diabetologia

JF - Diabetologia

IS - 10

ER -

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

Abstract

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