A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

C S Rose; N Grarup; N T Krarup; P Poulsen; L Wegner; Trine Nielsen; K Banasik; K Faerch; G Andersen; A Albrechtsen; K Borch-Johnsen; J O Clausen; T Jørgensen; A Vaag; O Pedersen; T Hansen

doi:10.1007/s00125-009-1463-z

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

C S Rose, N Grarup, N T Krarup, P Poulsen, L Wegner, Trine Nielsen, K Banasik, K Faerch, G Andersen, A Albrechtsen, K Borch-Johnsen, J O Clausen, T Jørgensen, A Vaag, O Pedersen, T Hansen

22 Citations (Scopus)

Abstract

An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported. In Danes we aimed to examine rs560887 in relation to plasma glucose and serum insulin responses following oral and i.v. glucose loads and in relation to hepatic glucose production during a hyperinsulinaemic-euglycaemic clamp. Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.

Original language	English
Journal	Diabetologia
Volume	52
Issue number	10
Pages (from-to)	2122-2129
Number of pages	8
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-009-1463-z
Publication status	Published - 2009

Keywords

ATP-Binding Cassette Transporters
Adult
Blood Glucose
Fasting
Female
Genotype
Glucose
Glucose Tolerance Test
Glucose-6-Phosphatase
Humans
Insulin
Liver
Male
Middle Aged

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-009-1463-z

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Rose, C. S., Grarup, N., Krarup, N. T., Poulsen, P., Wegner, L., Nielsen, T., Banasik, K., Faerch, K., Andersen, G., Albrechtsen, A., Borch-Johnsen, K., Clausen, J. O., Jørgensen, T., Vaag, A., Pedersen, O., & Hansen, T. (2009). A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads. Diabetologia, 52(10), 2122-2129. https://doi.org/10.1007/s00125-009-1463-z

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads. / Rose, C S; Grarup, N; Krarup, N T et al.
In: Diabetologia, Vol. 52, No. 10, 2009, p. 2122-2129.

Research output: Contribution to journal › Journal article › Research › peer-review

Rose, CS, Grarup, N, Krarup, NT, Poulsen, P, Wegner, L, Nielsen, T , Banasik, K , Faerch, K, Andersen, G, Albrechtsen, A, Borch-Johnsen, K, Clausen, JO, Jørgensen, T, Vaag, A , Pedersen, O & Hansen, T 2009, 'A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads', Diabetologia, vol. 52, no. 10, pp. 2122-2129. https://doi.org/10.1007/s00125-009-1463-z

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abstract = "An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported. In Danes we aimed to examine rs560887 in relation to plasma glucose and serum insulin responses following oral and i.v. glucose loads and in relation to hepatic glucose production during a hyperinsulinaemic-euglycaemic clamp. Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.",

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AU - Rose, C S

AU - Grarup, N

AU - Krarup, N T

AU - Poulsen, P

AU - Wegner, L

AU - Nielsen, Trine

AU - Banasik, K

AU - Faerch, K

AU - Andersen, G

AU - Albrechtsen, A

AU - Borch-Johnsen, K

AU - Clausen, J O

AU - Jørgensen, T

AU - Vaag, A

AU - Pedersen, O

AU - Hansen, T

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AB - An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported. In Danes we aimed to examine rs560887 in relation to plasma glucose and serum insulin responses following oral and i.v. glucose loads and in relation to hepatic glucose production during a hyperinsulinaemic-euglycaemic clamp. Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.

KW - ATP-Binding Cassette Transporters

KW - Adult

KW - Blood Glucose

KW - Fasting

KW - Female

KW - Genotype

KW - Glucose

KW - Glucose Tolerance Test

KW - Glucose-6-Phosphatase

KW - Humans

KW - Insulin

KW - Liver

KW - Male

KW - Middle Aged

U2 - 10.1007/s00125-009-1463-z

DO - 10.1007/s00125-009-1463-z

M3 - Journal article

C2 - 19669124

SN - 0012-186X

VL - 52

SP - 2122

EP - 2129

JO - Diabetologia

JF - Diabetologia

IS - 10

ER -

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

Abstract

Keywords

UN SDGs

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