Camilla Foged

2019

Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery

Thanki, K., Papai, S., Lokras, A., Rose, F., Falkenberg, E., Franzyk, H. & Foged, C., 1 mar. 2019, I: Pharmaceutical Research. 36, 3, s. 37

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

5 Citationer (Scopus)

Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration

Tandrup Schmidt, S., Line Olsen, C., Franzyk, H., Wørzner, K., Smith Korsholm, K., Rades, T., Andersen, P., Foged, C. & Christensen, D., jul. 2019, I: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 140, s. 29-39 11 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

59 Downloads (Pure)

Design of gadoteridol-loaded cationic liposomal adjuvant CAF01 for MRI of lung deposition of intrapulmonary administered particles

Thakur, A., Rose, F., Ansari, S. R., Koch, P., Martini, V., Ovesen, S. L., Quistorff, B., Maritim, S., Hyder, F., Andersen, P., Christensen, D., Mori, Y. & Foged, C., 30 aug. 2019, I: Molecular Pharmaceutics. 16, 11, s. 4725-4737 13 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

Design of Inhalable Solid Dosage Forms of Budesonide and Theophylline for Pulmonary Combination Therapy

Leng, D., Kissi, E. O., Löbmann, K., Thanki, K., Fattal, E., Rades, T., Foged, C. & Yang, M., 1 apr. 2019, I: AAPS PharmSciTech. 20, 3, s. 137

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

Dormenval, C., Lokras, A., Cano-Garcia, G., Wadhwa, A., Thanki, K., Rose, F., Thakur, A., Franzyk, H. & Foged, C., 1 okt. 2019, I: Pharmaceutical Research. 36, 10, s. 142

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

12 Citationer (Scopus)

Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model

Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, H., Nielsen, H. M., van Eden, W., Dong, M., Broere, F., Foged, C. & Zeng, X., sep. 2019, I: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

12 Citationer (Scopus)

Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling

Hansen, M., Peltier, J., Killy, B., Amin, B., Bodendorfer, B., Härtlova, A., Uebel, S., Bosmann, M., Hofmann, J., Büttner, C., Ekici, A. B., Kuttke, M., Franzyk, H., Foged, C., Beer-Hammer, S., Schabbauer, G., Trost, M. & Lang, R., apr. 2019, I: Molecular and Cellular Proteomics. 18, 4, s. 669-685

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

8 Citationer (Scopus)

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, H., Nielsen, H. M., Braeckmans, K., Lehr, C.-M., Ogris, M. & Foged, C., 28 sep. 2019, I: Journal of controlled release : official journal of the Controlled Release Society.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

15 Citationer (Scopus)

Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design

Borro, B. C., Bohr, A., Bucciarelli, S., Boetker, J. P., Foged, C., Rantanen, J. & Malmsten, M., 7 mar. 2019, I: Journal of Colloid and Interface Science. 538, s. 559-568 10 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

12 Citationer (Scopus)

Nebulised lipid-polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells

Vencken, S., Foged, C., Ramsey, J. M., Sweeney, L., Cryan, S.-A., MacLoughlin, R. J. & Greene, C. M., apr. 2019, I: ERJ Open Research. 5, 2

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Preparation, Characterization, and In Vitro Evaluation of Lipidoid-Polymer Hybrid Nanoparticles for siRNA Delivery to the Cytosol

Thanki, K., Zeng, X. & Foged, C., 2019, I: Methods in molecular biology (Clifton, N.J.). 1943, s. 141-152 12 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring

Wan, F., Nylander, T., Foged, C., Yang, M., Baldursdottir, S. G. & Nielsen, H. M., 1 jun. 2019, I: Journal of Colloid and Interface Science. 545, s. 162-171 10 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

8 Citationer (Scopus)

2018

Anchoring of hydrophilic coating polymers onto charged liposomes via attractive electrostatic interactions using charged tags to control the surface charge drainage properties and cellular targeting

Andersen, P. L. (Opfinder), Christensen, D. (Opfinder), Franzyk, H. (Opfinder), Foged, C. (Opfinder) & Schmidt, S. T. (Opfinder), 2018, (Afsendt)

Publikation: Patent

A strong adjuvant based on glycol-chitosan-coated lipid-polymer hybrid nanoparticles potentiates mucosal immune responses against the recombinant Chlamydia trachomatis fusion antigen CTH522

Rose, F., Erbo Wern, J., Gavins, F., Andersen, P., Follmann, F. & Foged, C., 10 feb. 2018, I: Journal of Controlled Release. 271, s. 88-97 10 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

19 Citationer (Scopus)

Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

Thakur, A., Rodríguez-Rodríguez, C., Saatchi, K., Rose, F., Esposito, T., Nosrati, Z., Andersen, P., Christensen, D., Häfeli, U. O. & Foged, C., 30 nov. 2018, I: Frontiers in Immunology. 9, 21 s., 2825.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

26 Downloads (Pure)

Engineering of budesonide-loaded lipid-polymer hybrid nanoparticles using a quality-by-design approach

Leng, D., Thanki, K., Fattal, E., Foged, C. & Yang, M., 15 sep. 2018, I: International Journal of Pharmaceutics. 548, 2, s. 740-746

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Formulating Inhalable Dry Powders Using Two-Fluid and Three-Fluid Nozzle Spray Drying

Leng, D., Thanki, K., Foged, C. & Yang, M., 1 dec. 2018, I: Pharmaceutical Research. 35, 12, 12 s., 247.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Formulation of RNA interference-based drugs for pulmonary delivery: challenges and opportunities

Thanki, K., Blum, K. G., Thakur, A., Rose, F. & Foged, C., okt. 2018, I: Therapeutic Delivery. 9, 10, s. 731-749 19 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities

Thanki, K., Falkenberg, E., Gangloff, M. & Foged, C., 31 aug. 2018, Immune Effects of Biopharmaceuticals and Nanomedicine. Bawa, R., Szebeni, J. & Audette, G. (red.). Pan Stanford, 32 s.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein

Rodrigues, L., Raftopoulos, K. N., Tandrup Schmidt, S., Schneider, F., Dietz, H., Rades, T., Franzyk, H., Pedersen, A. E., Papadakis, C. M., Christensen, D., Winter, G., Foged, C. & Hubert, M., 10 sep. 2018, I: Journal of controlled release : official journal of the Controlled Release Society. 285, s. 12-22 11 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, H., Nielsen, H. M., Broere, F., Gay, N. J., Foged, C. & Sijts, A. J. A. M., 1 jun. 2018, I: Molecular Therapy - Nucleic Acids. 11, s. 159-169 11 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

12 Citationer (Scopus)

97 Downloads (Pure)

Immunological and physical evaluation of the multistage tuberculosis subunit vaccine candidate H56/CAF01 formulated as a spray-dried powder

Thakur, A., Ingvarsson, P. T., Schmidt, S. T., Rose, F., Andersen, P., Christensen, D. & Foged, C., 31 maj 2018, I: Vaccine. 36, 23, s. 3331-3339 9 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Induction of Cytotoxic T-Lymphocyte Responses Upon Subcutaneous Administration of a Subunit Vaccine Adjuvanted With an Emulsion Containing the Toll-Like Receptor 3 Ligand Poly(I:C)

Schmidt, S. T., Pedersen, G. K., Neustrup, M. A., Korsholm, K. S., Rades, T., Andersen, P., Foged, C. & Christensen, D., 30 apr. 2018, I: Frontiers in Immunology. 9, 12 s.

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8 Citationer (Scopus)

44 Downloads (Pure)

Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation

Wan, F., Larsen, F. H., Nunes Bordallo, H., Foged, C., Rantanen, J. & Yang, M., 31 okt. 2018, I: A C S Applied Materials and Interfaces. 10, 43, s. 36686-36692

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

6 Citationer (Scopus)

Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M. & Braeckmans, K. & 1 flere, Foged, C., 2018.

Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms

Wan, F., Nylander, T., Klodzinska, S. N., Foged, C., Yang, M., Baldursdottir, S. G. & Mørck Nielsen, H., 4 apr. 2018, I: A C S Applied Materials and Interfaces. 10, 13, s. 10678–10687

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11 Citationer (Scopus)

Potential mucus rheological consequences of off target siRNA loaded nanoparticle deposition in the lungs

Katuwal, N., Loretz, B., Thanki, K., Hallbrink, M., Lehr, C.-M., Foged, C., Draget, K. & Nordgård, C. T., 2018, ANNUAL TRANSACTIONS OF THE NORDIC RHEOLOGY SOCIETY. Bind 26.

Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning

Selected contributions from the 10th European Workshop on Particulate Systems, Copenhagen 19th–20th January 2017

Foged, C., 15 sep. 2018, I: International Journal of Pharmaceutics. 548, 2, s. 729

Publikation: Bidrag til tidsskrift › Leder

Temperature-Induced Self-Assembly of the Group B Streptococcus (GBS) Fusion Antigen GBS-NN

Rose, F., Roovers, S., Fano, M., Harloff-Helleberg, S., Kirkensgaard, J. J. K., Hejnaes, K., Fischer, P. & Foged, C., 2 jul. 2018, I: Molecular Pharmaceutics. 15, s. 2584-2593 10 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein-Based Fusion Antigen CTH522 Into Protein Nanoparticles

Rose, F., Karlsen, K., Jensen, P. R., Jakobsen, R. U., Wood, G. K., Rand, K. D., Godiksen, H., Andersen, P., Follmann, F. & Foged, C., jun. 2018, I: Journal of Pharmaceutical Sciences. 107, 6, s. 1690-1700 11 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

2017

Adjuvants based on synthetic mycobacterial cord factor analogues: Biophysical properties of neat glycolipids and nano-self-assemblies with DDA

Kallerup, R. S., Franzyk, H., Schiøth, M. L., Justesen, S., Martin-Bertelsen, B., Rose, F., Madsen, C. M., Christensen, D., Korsholm, K. S., Yaghmur, A. & Foged, C., 3 jul. 2017, I: Molecular Pharmaceutics. 14, 7, s. 2294-2306 13 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

Advances in combination therapy of lung cancer: Rationales, delivery technologies and dosage regimens

Wu, L., Leng, D., Cun, D., Foged, C. & Yang, M., 28 aug. 2017, I: Journal of Controlled Release. 260, s. 78-91

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

27 Citationer (Scopus)

ANTI-INFLAMMATORY EFFECT OF ANTI-TNF-ALPHA siRNA CATIONIC PHOSPHOROUS DENDRIMERS NANOCOMPLEXES ADMINISTERED INTRANASALLY IN A MURINE ACUTE LUNG INJURY MODEL

Bohr, A., Tsapis, N., Andreana, I., Chamarat, A., Foged, C., Delomenie, C., Noiray, M., El Brahmi, N., Majoral, J.-P., Mignani, S. & Fattal, E., 21 jun. 2017, I: Biomacromolecules. 18, 8, s. 2379–2388

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

29 Citationer (Scopus)

Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs

Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, H. M., Franzyk, H. & Foged, C., 2017.

Publikation: Konferencebidrag › Poster › Forskning

Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach

Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, H. M., Franzyk, H. & Foged, C., nov. 2017, I: European Journal of Pharmaceutics and Biopharmaceutics. 120, s. 22-33 12 s.

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24 Citationer (Scopus)

Inhalable siRNA-loaded nano-embedded microparticles engineered using microfluidics and spray drying

Agnoletti, M., Bohr, A., Thanki, K., Wan, F., Zeng, X., Bøtker, J. P., Yang, M. & Foged, C., nov. 2017, I: European Journal of Pharmaceutics and Biopharmaceutics. 120, s. 9-21

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20 Citationer (Scopus)

Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

Foged, C. (Opfinder), Franzyk, H. (Opfinder), Zeng, X. (Opfinder), Nielsen, H. M. (Opfinder) & Thanki, K. (Opfinder), 21 sep. 2017, IPC nr. A61K31/713, A61K47/18, A61K47/34, A61K9/51, A61P25/00, A61P29/00, A61P35/00, Patentnr. WO2017158093-A1, 16 mar. 2017, Prioritetsdato 17 mar. 2016, Prioritetsnr. EP 2016-160931

Publikation: Patent

Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA

Zeng, X., Nielsen, H. M., Franzyk, H. & Foged, C., 2017.

Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning

Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy

Falkenberg, E., de Groot, A. M., Sijts, A. J. A. M., Thanki, K., Zeng, X., Nielsen, H. M., Franzyk, H. & Foged, C., 2017.

Publikation: Konferencebidrag › Poster › Forskning

Systematic investigation of the role of surfactant composition and choice of oil: Design of a nanoemulsion-based adjuvant inducing concomitant humoral and CD4+ T-cell responses

Schmidt, S. T., Neustrup, M. A., Harloff-Helleberg, S., Korsholm, K. S., Rades, T., Andersen, P., Christensen, D. & Foged, C., 1 aug. 2017, I: Pharmaceutical Research. 34, 8, s. 1716-1727 12 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

5 Citationer (Scopus)

2016

Conserved molecular superlattices in a series of homologous synthetic mycobacterial cell-wall lipids forming interdigitated bilayers

Martin-Bertelsen, B., Yaghmur, A., Franzyk, H., Justesen, S., Kirkensgaard, J. J. K. & Foged, C., 6 dec. 2016, I: Langmuir. 32, 48, s. 12693–12701 9 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

2 Citationer (Scopus)

Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.

Jing, X., Foged, C., Martin-Bertelsen, B., Yaghmur, A., Knapp, K. M., Malmsten, M., Franzyk, H. & Nielsen, H. M., 6 jun. 2016, I: Molecular Pharmaceutics. 13, 6, s. 1739-1749 11 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

10 Citationer (Scopus)

Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.

Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Ogris, M., Nielsen, H. M. & Foged, C., 2016.

Publikation: Konferencebidrag › Poster › Forskning

Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators

Schmidt, S. T., Foged, C., Korsholm, K. S., Rades, T. & Christensen, D., 10 mar. 2016, I: Pharmaceutics. 8, 1, 22 s., 7.

Publikation: Bidrag til tidsskrift › Review › peer review

84 Citationer (Scopus)

Nano-self-assemblies based on synthetic analogues of mycobacterial monomycoloyl glycerol and DDA: Supramolecular structure and adjuvant efficacy

Martin-Bertelsen, B., Korsholm, K. S., Christensen, D., Franzyk, H., Yaghmur, A. & Foged, C., 1 aug. 2016, I: Molecular Pharmaceutics. 13, 8, s. 2771-2781 11 s.

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9 Citationer (Scopus)

The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8(+) T-cell responses: The immunological consequences of the biodistribution profile

Schmidt, S. T., Khadke, S., Korsholm, K. S., Perrie, Y., Rades, T., Andersen, P., Foged, C. & Christensen, D., 10 okt. 2016, I: Journal of controlled release : official journal of the Controlled Release Society. 239, s. 107-117 11 s.

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34 Citationer (Scopus)

Thermostable Subunit Vaccines for Pulmonary Delivery: How Close Are We?

Foged, C., 1 maj 2016, I: Current Pharmaceutical Design. 22, 17, s. 2561-2576 16 s.

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10 Citationer (Scopus)

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages invitro and adjuvant activity invivo

Huber, A., Kallerup, R. S., Korsholm, K. S., Franzyk, H., Lepenies, B., Christensen, D., Foged, C. & Lang, R., 1 aug. 2016, I: Innate Immunity. 22, 6, s. 405-418 14 s.

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30 Citationer (Scopus)

2015

Biophysical and nanostructural properties of trehalose 6-mono and 6,6’-diesters

Madsen, C. M., Martin-Bertelsen, B., Kallerup, R. S., Rose, F., Christensen, D., Yaghmur, A., Franzyk, H. & Foged, C., 2015. 1 s.

Publikation: Konferencebidrag › Poster › Forskning

Characterizing the association between antigens and adjuvants

Jensen, M. H. & Foged, C., 2015, Subunit vaccine delivery. London, s. 413-426 14 s.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

Camilla Foged

Publikation

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