Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

Camilla Foged; Henrik Franzyk; Xianghui Zeng; Hanne Mørck Nielsen; Kaushik Thanki

Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

Camilla Foged (Opfinder), Henrik Franzyk (Opfinder), Xianghui Zeng (Opfinder), Hanne Mørck Nielsen (Opfinder), Kaushik Thanki (Opfinder)

Abstract

The present invention relates to a nanoparticle compn. comprising PLGA derivs. and a lipid. The compn. is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.

Originalsprog	Engelsk
IPC	A61K31/713,A61K47/18,A61K47/34,A61K9/51,A61P25/00,A61P29/00,A61P35/00
Patentnummer	WO2017158093-A1
Journaliseringsdato	16/03/2017
Land/Område	Danmark
Prioritetsdato	17/03/2016
Prioritetsnummer	EP 2016-160931
Status	Udgivet - 21 sep. 2017

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https://worldwide.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20170921&CC=WO&NR=2017158093A1&KC=A1

Citationsformater

Foged, C., Franzyk, H., Zeng, X., Nielsen, H. M., & Thanki, K. (2017). Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA. (Patentnummer WO2017158093-A1). https://worldwide.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20170921&CC=WO&NR=2017158093A1&KC=A1

Foged, C , Franzyk, H, Zeng, X, Nielsen, HM & Thanki, K sep.. 21 2017, Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA, Patentnummer WO2017158093-A1. <https://worldwide.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20170921&CC=WO&NR=2017158093A1&KC=A1>

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title = "Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA",

abstract = "The present invention relates to a nanoparticle compn. comprising PLGA derivs. and a lipid. The compn. is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.",

author = "Camilla Foged and Henrik Franzyk and Xianghui Zeng and Nielsen, {Hanne M{\o}rck} and Kaushik Thanki",

year = "2017",

month = sep,

day = "21",

language = "English",

type = "Patent",

note = "WO2017158093-A1; A61K31/713,A61K47/18,A61K47/34,A61K9/51,A61P25/00,A61P29/00,A61P35/00",

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TY - PAT

T1 - Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

AU - Foged, Camilla

AU - Franzyk, Henrik

AU - Zeng, Xianghui

AU - Nielsen, Hanne Mørck

AU - Thanki, Kaushik

PY - 2017/9/21

Y1 - 2017/9/21

N2 - The present invention relates to a nanoparticle compn. comprising PLGA derivs. and a lipid. The compn. is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.

AB - The present invention relates to a nanoparticle compn. comprising PLGA derivs. and a lipid. The compn. is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.

M3 - Patent

M1 - WO2017158093-A1

Y2 - 2017/03/16

ER -

Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

Abstract

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