The FANCM family Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability

TY - JOUR

T1 - The FANCM family Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability

AU - Bernal, Manuel

AU - Yang, Xuejiao

AU - Lisby, Michael

AU - Mazón, Gerard

PY - 2019

Y1 - 2019

N2 - Mitochondria are membrane-bound organelles found in eukaryotic cells where they generate energy through the respiratory chain. They contain their own genome that encodes genes critical to the mitochondrial function, but most of their protein content is synthetized from nuclear encoded genes. Damages to the mtDNA can cause mutations and rearrangements with an impact on the respiratory functions of the cell. DNA repair factors are able to localize to mitochondria to restore mtDNA integrity and ensure its proper inheritance. We describe in this article the mitochondrial localization of the Mph1/FANCM helicase that serves critical roles in nuclear DNA repair processes. Mph1 localizes to mitochondria and its functions contribute to the mtDNA integrity under mtDNA damaging conditions.

AB - Mitochondria are membrane-bound organelles found in eukaryotic cells where they generate energy through the respiratory chain. They contain their own genome that encodes genes critical to the mitochondrial function, but most of their protein content is synthetized from nuclear encoded genes. Damages to the mtDNA can cause mutations and rearrangements with an impact on the respiratory functions of the cell. DNA repair factors are able to localize to mitochondria to restore mtDNA integrity and ensure its proper inheritance. We describe in this article the mitochondrial localization of the Mph1/FANCM helicase that serves critical roles in nuclear DNA repair processes. Mph1 localizes to mitochondria and its functions contribute to the mtDNA integrity under mtDNA damaging conditions.

KW - Double-strand break

KW - Fanconi Anemia-like pathway

KW - Helicase Mph1

KW - Homologous recombination

KW - Mitochondrial DNA repair

U2 - 10.1016/j.dnarep.2019.102684

DO - 10.1016/j.dnarep.2019.102684

M3 - Journal article

C2 - 31569000

AN - SCOPUS:85072635055

SN - 1568-7864

VL - 82

JO - DNA Repair

JF - DNA Repair

M1 - 102684

ER -