Vaccines and multiple sclerosis: a systematic review

Mia Topsøe Mailand, Jette Lautrup Frederiksen*

*Corresponding author for this work
45 Citations (Scopus)

Abstract

Vaccinations are often the most effective tool against some disease known to mankind. This study offers a literature review on the role of vaccines regarding the risk of developing multiple sclerosis (MS) and MS relapse. The method used in this study is a systematic literature review on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles–mumps–rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse was found for influenza. Further research is needed for the potential therapeutic use of the BCG vaccine in patients in risk of developing MS and for the preventive potential of the tetanus and diphtheria vaccine.

Original languageEnglish
JournalJournal of Neurology
Volume264
Issue number6
Pages (from-to)1035-1050
Number of pages16
ISSN0340-5354
DOIs
Publication statusPublished - 2017

Keywords

  • Immunization
  • Multiple sclerosis
  • Vaccination

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