Vaccines and multiple sclerosis: a systematic review

TY - JOUR

T1 - Vaccines and multiple sclerosis

T2 - a systematic review

AU - Mailand, Mia Topsøe

AU - Frederiksen, Jette Lautrup

PY - 2017

Y1 - 2017

N2 - Vaccinations are often the most effective tool against some disease known to mankind. This study offers a literature review on the role of vaccines regarding the risk of developing multiple sclerosis (MS) and MS relapse. The method used in this study is a systematic literature review on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles–mumps–rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse was found for influenza. Further research is needed for the potential therapeutic use of the BCG vaccine in patients in risk of developing MS and for the preventive potential of the tetanus and diphtheria vaccine.

AB - Vaccinations are often the most effective tool against some disease known to mankind. This study offers a literature review on the role of vaccines regarding the risk of developing multiple sclerosis (MS) and MS relapse. The method used in this study is a systematic literature review on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles–mumps–rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse was found for influenza. Further research is needed for the potential therapeutic use of the BCG vaccine in patients in risk of developing MS and for the preventive potential of the tetanus and diphtheria vaccine.

KW - Immunization

KW - Multiple sclerosis

KW - Vaccination

U2 - 10.1007/s00415-016-8263-4

DO - 10.1007/s00415-016-8263-4

M3 - Review

C2 - 27604618

AN - SCOPUS:84986313430

SN - 0939-1517

VL - 264

SP - 1035

EP - 1050

JO - Deutsche Zeitschrift fur Nervenheilkunde

JF - Deutsche Zeitschrift fur Nervenheilkunde

IS - 6

ER -