Abstract
OBJECTIVE - We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality. RESEARCH DESIGN ANDMETHODS - We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-27prime;-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-termmortality using Cox proportional hazards regression. RESULTS - After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively.Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses. CONCLUSIONS - Urinary excretion of the RNA oxidationmarker 8-oxoGuomeasured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes.
| Translated title of the contribution | Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients |
|---|---|
| Original language | English |
| Journal | Diabetes Care |
| Volume | 34 |
| Issue number | 12 |
| Pages (from-to) | 2594-2596 |
| Number of pages | 3 |
| ISSN | 0149-5992 |
| DOIs | |
| Publication status | Published - Dec 2011 |
Keywords
- Denmark
- diabetes
- diagnosis
- methods
- Mortality
- PATIENT
- Patients
- pharmacology
- Research
- Research Design
- Risk
- RISK-FACTORS
- Risk Factors
- semrap-2011-3
- Support
