Niels de Fine Olivarius

Short presentation

My main interest is clinical epidemiology. I wish e.g. to make analyses of follow up data from general practice usable for clinicians - including finding a way from the generalizations of epidemiology to the individualization of treatments in daily clinical work. Doing this, I have often used diabetes as a model disease. In recent years I have had an increasing focus on clinical biochemistry and multimorbidity using national registries, established study cohorts and clinical databases. Comorbidity remains, however, an important research topic when it comes to improving the quality of the treatment of patients with multiple chronic diseases in general practice – e.g. when it comes to screening for and intensifying treatment of physical diseases in patients with severe mental illness.

Primary fields of research

Clinical epidemiology (including intervention research / randomized trials, cohort studies and registry research), clinical biochemistry, health services research, diabetes (including mortality, weight, course of treatment and diabetic retinopathy), multimorbidity, comorbidity, research guidance, dynamic strategy development.

Current research

Involved in the planning, development, execution and analysis of e.g. "The Diabetes Care in General Practice (DCGP) Study", "The Copenhagen Primary Care Differential Count (CopDiff) Database", "The Copenhagen Primary Care Laboratory (CopLab) Database", "Asthma and Bronchiolitis in Children in General Practice", and "A cluster randomised, parallel-group, 5-year trial of coordinated, co-produced care to reduce the excess mortality of patients with severe mental illness by improving the treatment of their comorbid physical conditions (The Phy-Psy Trial)."

Teaching

Vejleder for ph.d.-studerende og specialestuderende ved det Sundhedsvidenskabelige Fakultet, Københavns Universitet.

CV

Personal details: Date of birth: 10 January 1951. Address: Hostrups Have 58, 5 tv, DK-1954 Frederiksberg C, Denmark. Mobile number: +45 6130 8547. E-mail: [email protected]. www: http://fe.ku.dk/medarbejdere/niels/. Married. Five children, born in 1983, 1984, 1991, 1994 & 1996.

Education and current employment: 1975: BSc (biochemistry), University of Copenhagen. 1981: MD, University of Copenhagen. 2003: Diploma in Development Management (2-year course), Ankerhus Management College, Denmark and Norway. Since 1986, head of the study, “Diabetes Care in General Practice”, a pioneering project in the field of interna-tional general practice intervention research, which at present involves a group of 12 researchers. 2001-2016, Assistant Research Director at the RUGP. Since 2010, Professor of General Practice at the Department of Public Health, University of Copenhagen.

Teaching posts, courses, congresses: Lecturer at about 70 courses and arranged 20 of these. Contributions made at 100+ international congresses and professional meetings and at 70 Danish and Scandinavian meetings. Subjects: Research methodology (randomised controlled trials, multi-practice research, registry research), research on diabetes treatment methods, as well as general practice and epidemiological research.

Research guidance and professional honors: Tutor/adviser for 10 PhD-graduates and main adviser for several projects headed by general practitioners. Active in developing the subject of general practice through the National Board of Health, University of Copenhagen, the Danish Association of General Practitioners, Danish Endocrine Society, Danish Society of Internal Medicine, Danish Centre for Health Technology Assessment, and other scientific associations. Reviewer for ca. 20 international scientific journals. Has received 4 honorary prizes for general practice research.

Publications: Have had ca. 110 original scientific papers published in peer-reviewed journals of which 80% have been published since 2000. First author on 35% of the articles. The articles cover a wide range of clinical and methodological subjects. The main emphasis in the articles has been on treatment methods and clinical epidemiology as well as methods research in the field of clinical biochemistry and register and questionnaire research. Selected publications:

Olivarius NdeF, Beck-Nielsen H, Andreasen AH, Hørder M, Pedersen PA. Randomised controlled trial of structured personal care of type 2 diabetes mellitus. BMJ 2001; 323: 970-5.

Olivarius NdeF, Nielsen NV, Andreasen AH. Diabetic retinopathy in newly diagnosed middle-aged and elderly diabetic patients. Prevalence and interrelationship with microalbuminuria and triglycerides. Graefe Arch Clin Exp Ophthalmol 2001; 239: 664-72.

Astrup K, Olivarius NdeF, Møller S, Gottschau A, Karlslund W. Menstrual bleeding patterns in pre- and perimenupausal women: a population-based prospective diary study. Acta Obstet Gynecol Scand 2004; 83: 197-202.

Heldgaard PE, Olivarius NdeF, Hindsberger C, Henriksen JE. Impaired fasting glycaemia resembles impaired glucose tolerance with regard to cardiovascular risk factors: population-based, cross-sectional study of risk factors for cardiovascular disease. Diabet Med 2004; 21: 363-70.

Olivarius NdeF. Diabetes care today: not everyone should have intensive multipharmacological treatment. Scand J Prim Health Care 2004; 22: 67-70.

Olivarius NdeF, Palmvig B, Andreasen AH, Thorgersen JT, Hundrup C. An educational model for improving diet counselling in primary care. A case study of the creative use of doctors’ own diet, their attitudes to it and to nutritional counselling of their own patients with diabetes. Patient Educ Counsel 2005; 58: 199-202.

Olivarius NdeF, Andreasen AH, Siersma V, Richelsen B, Beck-Nielsen H. Changes in patient weight and the impact of antidiabetic therapy during the first 5 years after diagnosis of diabetes mellitus. Diabetologia 2006; 49: 2058-2067.

Hermann C, Olivarius NdeF, Høst A, Begtrup K, Hollnagel H. Prevalence, severity and determinants of asthma in Danish five-year-olds. Acta Pædiatrica 2006; 95: 1182-1190.

Olivarius NdeF, Siersma V, Almind GJ, Vesti Nielsen N. Prevalence and progression of visual impairment in patients newly diagnosed with clinical type 2 diabetes: a 6-year follow up study. BMC Public Health 2011; 11: 80.

Nielsen ABS, Gannik D, Siersma V, Olivarius NdeF. The relationship between HbA1c level, symptoms and self-rated health in type 2 diabetic patients. Scand J Prim Health Care 2011, early online, 1-8.

Hansen LJ, Siersma V, Beck-Nielsen H, Olivarius NdeF. Structured personal care of type 2 diabetes: a 19 year follow-up of the study Diabetes Care in General Practice (DCGP). Diabetologia 2013; 56: 1243-53.

Brødbaek K, Siersma V, T Henriksen, Weimann A, Petersen M, Andersen JT, Jimenez-Solem E, Hansen LJ, Henriksen JE, Bonnema SJ, Olivarius NdeF, Poulsen HE. Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study. Diabetes Care 2013; 36: 669-676.

Andersen CL, Siersma VD, Hasselbalch HC, Lindegaard H, Vestergaard H, Felding P, Olivarius NdeF, Bjerrum OW. Eosinophilia in routine blood samples as a biomarker for solid tumor development - A study based on The Copenhagen Primary Care Differential Count (CopDiff) Database. Acta Oncologica 2014; 53 (9): 1245-1250.

Lundström H, Siersma V, Sternhagen Nielsen AB, Brodersen J, Reventlow S, Kragh Andersen P, Olivarius NdeF. The effectiveness of structured personal care of type 2 diabetes on recurrent outcomes. A 19-year follow-up of the study Diabetes Care in General Practice (DCGP). Diabetologia 2014; 57: 1119-1123.

Andersen CL, Siersma VD, Karlslund W, Hasselbalch HC, Felding P, Bjerrum OW, Olivarius NdeF. The Copenhagen Primary Care Differential Count (CopDiff) Database. Clin Epidemiol 2014: 6: 199-211.

Bruun C, Guassora AD, Nielsen ABS,Siersma V, Holstein PE, Olivarius NdeF. Motivation, effort and life circumstances as predictors of foot ulcers and amputations in people with Type 2 diabetes mellitus. Diabet Med 2014; 31 (11): 1468-1476.

Olivarius NdeF, Siersma V, Køster-Rasmussen K, Heitmann B, Waldorff FB. Weight changes following the diagnosis of type 2 diabetes: the impact of recent and past weight history before diagnosis. Results from the Danish Diabetes Care in General Practice (DCGP) study. PLoS One 2015;10 (4): e0122219.

Køster-Rasmussen R, Permin CA, Siersma V, Henriksen JE, Heitmann BL, Heldgaard PE, Olivarius NdeF. Back on track - Smoking cessation and weight changes over 9 years in a community-based cohort study. Prev Med 2015; 81:320-325.

Krag MØ, Hasselbalch L, Siersma V, Nielsen AB, Reventlow S, Malterud K, Olivarius NdeF. The impact of gender on the long-term morbidity and mortality of patients with type 2 diabetes receiving structured personal care: a 13 year follow-up study. Diabetologia 2016; 59: 275–285.

Larsen JR, Siersma VD, Davidsen AS, Waldorff FB, Reventlow S, Olivarius NdeF. The excess mortality of patients with diabetes and concurrent psychiatric illness is markedly reduced by structured personal diabetes care: A 19-year follow up of the randomized controlled study Diabetes Care in General Practice (DCGP). Gen Hosp Psychiatry 2016; 38: 41-52.

Willadsen TG, Bebe A, Køster-Rasmussen R, Jarbøl DE, Guassora AD, Waldorff FB, Reventlow S, Olivarius NdeF. The role of diagnoses, risk factors, and symptoms in the definition of multimorbidity - a systematic review. Scand J Prim Health Care 2016; 34(2): 112-121.

Køster-Rasmussen R, Simonsen MK, Siersma V, Henriksen JE, Heitmann BL, Olivarius NdeF. Intentional weight loss and longevity in overweight patients with type 2 diabetes: a population based inception cohort. PLoS ONE 2016; 11(1): e0146889.