Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients

K. Broedbaek; Volkert Dirk Siersma; T. Henriksen; A. Weimann; M. Petersen; J.T. Andersen; E. Jimenez-Solem; E.S. Stovgaard; L.J. Hansen; J.E. Henriksen; Steen Joop Bonnema; Niels de Fine Olivarius; H.E. Poulsen

doi:http://dx.doi.org/10.2337/dc11-1620

Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients

Bidragets oversatte titel: Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients

K. Broedbaek, Volkert Dirk Siersma, T. Henriksen, A. Weimann, M. Petersen, J.T. Andersen, E. Jimenez-Solem, E.S. Stovgaard, L.J. Hansen, J.E. Henriksen, Steen Joop Bonnema, Niels de Fine Olivarius, H.E. Poulsen

74 Citationer (Scopus)

Abstract

OBJECTIVE: We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality. RESEARCH DESIGN AND METHODS: We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-term mortality using Cox proportional hazards regression. RESULTS: After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively. Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses. CONCLUSIONS: Urinary excretion of the RNA oxidation marker 8-oxoGuo measured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes

Bidragets oversatte titel	Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients
Originalsprog	Engelsk
Tidsskrift	Diabetes Care
Vol/bind	34
Udgave nummer	12
Sider (fra-til)	2594-2596
Antal sider	3
ISSN	0149-5992
DOI	https://doi.org/10.2337/dc11-1620
Status	Udgivet - dec. 2011

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Broedbaek, K., Siersma, V. D., Henriksen, T., Weimann, A., Petersen, M., Andersen, J. T., Jimenez-Solem, E., Stovgaard, E. S., Hansen, L. J., Henriksen, J. E., Bonnema, S. J., Olivarius, N. D. F., & Poulsen, H. E. (2011). Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients. Diabetes Care, 34(12), 2594-2596. https://doi.org/10.2337/dc11-1620

Broedbaek, K, Siersma, VD, Henriksen, T, Weimann, A, Petersen, M, Andersen, JT, Jimenez-Solem, E, Stovgaard, ES, Hansen, LJ, Henriksen, JE, Bonnema, SJ, Olivarius, NDF & Poulsen, HE 2011, 'Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients', Diabetes Care, bind 34, nr. 12, s. 2594-2596. https://doi.org/10.2337/dc11-1620

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title = "Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients",

abstract = "OBJECTIVE - We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality. RESEARCH DESIGN ANDMETHODS - We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-27prime;-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-termmortality using Cox proportional hazards regression. RESULTS - After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively.Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses. CONCLUSIONS - Urinary excretion of the RNA oxidationmarker 8-oxoGuomeasured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes.",

keywords = "Denmark, diabetes, diagnosis, methods, Mortality, PATIENT, Patients, pharmacology, Research, Research Design, Risk, RISK-FACTORS, Risk Factors, semrap-2011-3, Support",

author = "K. Broedbaek and Siersma, {Volkert Dirk} and T. Henriksen and A. Weimann and M. Petersen and J.T. Andersen and E. Jimenez-Solem and E.S. Stovgaard and L.J. Hansen and J.E. Henriksen and Bonnema, {Steen Joop} and Olivarius, {Niels de Fine} and H.E. Poulsen",

note = "DA - 20111123 IS - 1935-5548 (Electronic) IS - 0149-5992 (Linking) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't SB - IM",

year = "2011",

month = dec,

doi = "http://dx.doi.org/10.2337/dc11-1620",

language = "English",

volume = "34",

pages = "2594--2596",

journal = "Diabetes Care",

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TY - JOUR

T1 - Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients

AU - Broedbaek, K.

AU - Siersma, Volkert Dirk

AU - Henriksen, T.

AU - Weimann, A.

AU - Petersen, M.

AU - Andersen, J.T.

AU - Jimenez-Solem, E.

AU - Stovgaard, E.S.

AU - Hansen, L.J.

AU - Henriksen, J.E.

AU - Bonnema, Steen Joop

AU - Olivarius, Niels de Fine

AU - Poulsen, H.E.

N1 - DA - 20111123 IS - 1935-5548 (Electronic) IS - 0149-5992 (Linking) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't SB - IM

PY - 2011/12

Y1 - 2011/12

N2 - OBJECTIVE - We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality. RESEARCH DESIGN ANDMETHODS - We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-27prime;-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-termmortality using Cox proportional hazards regression. RESULTS - After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively.Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses. CONCLUSIONS - Urinary excretion of the RNA oxidationmarker 8-oxoGuomeasured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes.

AB - OBJECTIVE - We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality. RESEARCH DESIGN ANDMETHODS - We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-27prime;-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-termmortality using Cox proportional hazards regression. RESULTS - After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively.Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses. CONCLUSIONS - Urinary excretion of the RNA oxidationmarker 8-oxoGuomeasured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes.

KW - Denmark

KW - diabetes

KW - diagnosis

KW - methods

KW - Mortality

KW - PATIENT

KW - Patients

KW - pharmacology

KW - Research

KW - Research Design

KW - Risk

KW - RISK-FACTORS

KW - Risk Factors

KW - semrap-2011-3

KW - Support

U2 - http://dx.doi.org/10.2337/dc11-1620

DO - http://dx.doi.org/10.2337/dc11-1620

M3 - Journal article

SN - 0149-5992

VL - 34

SP - 2594

EP - 2596

JO - Diabetes Care

JF - Diabetes Care

IS - 12

ER -

Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients

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