Urinary bisphenol A concentrations are associated with abnormal liver function in the elderly: a repeated panel study

TY - JOUR

T1 - Urinary bisphenol A concentrations are associated with abnormal liver function in the elderly

T2 - a repeated panel study

AU - Lee, Mee-Ri

AU - Park, Hyunseung

AU - Bae, Sanghyuk

AU - Lim, Youn-Hee

AU - Kim, Jin Hee

AU - Cho, Soo-Hun

AU - Hong, Yun-Chul

PY - 2014

Y1 - 2014

N2 - Background Bisphenol A (4,40-isopropylidenediphenol, BPA) is known to adversely affect various organs. The liver is reported to be affected by BPA in animal studies. However, there are few studies in humans on the effects of BPA on the liver. Therefore, we evaluated the relationship between urinary BPA levels and liver function in elderly subjects using repeated measurements. Methods From 2008 to 2010, a total of 560 elderly subjects residing in Seoul were each evaluated up to three times. At the first visit, demographic data, environmental exposure and lifestyle information were obtained from a systemised questionnaire. At each visit, blood and urine samples were collected and stored for analysis. Linear mixed and GLIMMIX model analyses were performed after adjusting for age, sex, Body Mass Index, alcohol consumption, urinary cotinine concentrations, exercise frequency, and low-density lipoprotein cholesterol level. Results The mean urinary BPA concentration was 1.13 μg/g creatinine. Significant relationships were observed between urinary BPA and aspartate aminotransferase, alanine aminotransferase, and gammaglutamyl transferase after adjusting for potential confounders (p<0.05). When subjects were grouped according to urinary BPA concentrations divided by the median value, higher urinary BPA concentrations were associated with increased abnormal liver function (OR 2.66; 95% CI 1.15 to 5.90). Conclusions Community-level exposure to BPA was associated with abnormal liver function in the elderly, indicating that more stringent control of BPA is necessary to protect susceptible populations.

AB - Background Bisphenol A (4,40-isopropylidenediphenol, BPA) is known to adversely affect various organs. The liver is reported to be affected by BPA in animal studies. However, there are few studies in humans on the effects of BPA on the liver. Therefore, we evaluated the relationship between urinary BPA levels and liver function in elderly subjects using repeated measurements. Methods From 2008 to 2010, a total of 560 elderly subjects residing in Seoul were each evaluated up to three times. At the first visit, demographic data, environmental exposure and lifestyle information were obtained from a systemised questionnaire. At each visit, blood and urine samples were collected and stored for analysis. Linear mixed and GLIMMIX model analyses were performed after adjusting for age, sex, Body Mass Index, alcohol consumption, urinary cotinine concentrations, exercise frequency, and low-density lipoprotein cholesterol level. Results The mean urinary BPA concentration was 1.13 μg/g creatinine. Significant relationships were observed between urinary BPA and aspartate aminotransferase, alanine aminotransferase, and gammaglutamyl transferase after adjusting for potential confounders (p<0.05). When subjects were grouped according to urinary BPA concentrations divided by the median value, higher urinary BPA concentrations were associated with increased abnormal liver function (OR 2.66; 95% CI 1.15 to 5.90). Conclusions Community-level exposure to BPA was associated with abnormal liver function in the elderly, indicating that more stringent control of BPA is necessary to protect susceptible populations.

KW - Aged

KW - Aged, 80 and over

KW - Alkaline Phosphatase/blood

KW - Benzhydryl Compounds/urine

KW - Biomarkers/blood

KW - Body Mass Index

KW - Environmental Exposure

KW - Environmental Pollutants/urine

KW - Female

KW - Humans

KW - L-Lactate Dehydrogenase/blood

KW - Liver Diseases/blood

KW - Liver Function Tests

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Phenols/urine

KW - Republic of Korea

KW - Tandem Mass Spectrometry

KW - gamma-Glutamyltransferase/blood

U2 - 10.1136/jech-2013-202548

DO - 10.1136/jech-2013-202548

M3 - Journal article

C2 - 24285822

SN - 0143-005X

VL - 68

SP - 312

EP - 317

JO - Journal of Epidemiology & Community Health

JF - Journal of Epidemiology & Community Health

IS - 4

ER -