TY - JOUR
T1 - Urinary bisphenol A concentrations are associated with abnormal liver function in the elderly
T2 - a repeated panel study
AU - Lee, Mee-Ri
AU - Park, Hyunseung
AU - Bae, Sanghyuk
AU - Lim, Youn-Hee
AU - Kim, Jin Hee
AU - Cho, Soo-Hun
AU - Hong, Yun-Chul
PY - 2014
Y1 - 2014
N2 - Background Bisphenol A (4,40-isopropylidenediphenol, BPA) is known to adversely affect various organs. The liver is reported to be affected by BPA in animal studies. However, there are few studies in humans on the effects of BPA on the liver. Therefore, we evaluated the relationship between urinary BPA levels and liver function in elderly subjects using repeated measurements. Methods From 2008 to 2010, a total of 560 elderly subjects residing in Seoul were each evaluated up to three times. At the first visit, demographic data, environmental exposure and lifestyle information were obtained from a systemised questionnaire. At each visit, blood and urine samples were collected and stored for analysis. Linear mixed and GLIMMIX model analyses were performed after adjusting for age, sex, Body Mass Index, alcohol consumption, urinary cotinine concentrations, exercise frequency, and low-density lipoprotein cholesterol level. Results The mean urinary BPA concentration was 1.13 μg/g creatinine. Significant relationships were observed between urinary BPA and aspartate aminotransferase, alanine aminotransferase, and gammaglutamyl transferase after adjusting for potential confounders (p<0.05). When subjects were grouped according to urinary BPA concentrations divided by the median value, higher urinary BPA concentrations were associated with increased abnormal liver function (OR 2.66; 95% CI 1.15 to 5.90). Conclusions Community-level exposure to BPA was associated with abnormal liver function in the elderly, indicating that more stringent control of BPA is necessary to protect susceptible populations.
AB - Background Bisphenol A (4,40-isopropylidenediphenol, BPA) is known to adversely affect various organs. The liver is reported to be affected by BPA in animal studies. However, there are few studies in humans on the effects of BPA on the liver. Therefore, we evaluated the relationship between urinary BPA levels and liver function in elderly subjects using repeated measurements. Methods From 2008 to 2010, a total of 560 elderly subjects residing in Seoul were each evaluated up to three times. At the first visit, demographic data, environmental exposure and lifestyle information were obtained from a systemised questionnaire. At each visit, blood and urine samples were collected and stored for analysis. Linear mixed and GLIMMIX model analyses were performed after adjusting for age, sex, Body Mass Index, alcohol consumption, urinary cotinine concentrations, exercise frequency, and low-density lipoprotein cholesterol level. Results The mean urinary BPA concentration was 1.13 μg/g creatinine. Significant relationships were observed between urinary BPA and aspartate aminotransferase, alanine aminotransferase, and gammaglutamyl transferase after adjusting for potential confounders (p<0.05). When subjects were grouped according to urinary BPA concentrations divided by the median value, higher urinary BPA concentrations were associated with increased abnormal liver function (OR 2.66; 95% CI 1.15 to 5.90). Conclusions Community-level exposure to BPA was associated with abnormal liver function in the elderly, indicating that more stringent control of BPA is necessary to protect susceptible populations.
KW - Aged
KW - Aged, 80 and over
KW - Alkaline Phosphatase/blood
KW - Benzhydryl Compounds/urine
KW - Biomarkers/blood
KW - Body Mass Index
KW - Environmental Exposure
KW - Environmental Pollutants/urine
KW - Female
KW - Humans
KW - L-Lactate Dehydrogenase/blood
KW - Liver Diseases/blood
KW - Liver Function Tests
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Phenols/urine
KW - Republic of Korea
KW - Tandem Mass Spectrometry
KW - gamma-Glutamyltransferase/blood
U2 - 10.1136/jech-2013-202548
DO - 10.1136/jech-2013-202548
M3 - Journal article
C2 - 24285822
SN - 0143-005X
VL - 68
SP - 312
EP - 317
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
IS - 4
ER -