Typing of 49 autosomal SNPs by SNaPshot in the Slovenian population

Katja Drobnic; Claus Børsting; Eszter Rockenbauer; Carmen Tomas; Niels Morling

doi:10.1016/j.fsigen.2010.01.014

Typing of 49 autosomal SNPs by SNaPshot in the Slovenian population

Katja Drobnic, Claus Børsting, Eszter Rockenbauer, Carmen Tomas, Niels Morling

11 Citations (Scopus)

Abstract

A total of 157 unrelated individuals residing in Slovenia were typed for 49 of the autosomal single nucleotide polymorphisms (SNPs) in the SNPforID 52plex with the SNaPshot^® assay. We obtained full SNP profiles in all but one individual and perfect concordance was obtained in duplicated analyses. Allele frequencies are presented for the 49 SNPs. No deviation from HWE was observed for any SNP. F_IS and F_ST were estimated. A principal coordinate analysis performed on six populations (Slovenian, Danish, Somali, Greenland, Turkish and Chinese) showed that the Slovenian population grouped with the Danish population. The mean power of discrimination for the Slovenian population was 1.1 × 10^-19, and the mean exclusion probability for trios was 99.96%.

Original language	English
Journal	Forensic Science International: Genetics
Volume	4
Issue number	5
Pages (from-to)	e125-7
Number of pages	3
ISSN	1872-4973
DOIs	https://doi.org/10.1016/j.fsigen.2010.01.014
Publication status	Published - Oct 2010

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title = "Typing of 49 autosomal SNPs by SNaPshot in the Slovenian population",

abstract = "A total of 157 unrelated individuals residing in Slovenia were typed for 49 of the autosomal single nucleotide polymorphisms (SNPs) in the SNPforID 52plex with the SNaPshot{\textregistered} assay. We obtained full SNP profiles in all but one individual and perfect concordance was obtained in duplicated analyses. Allele frequencies are presented for the 49 SNPs. No deviation from HWE was observed for any SNP. FIS and FST were estimated. A principal coordinate analysis performed on six populations (Slovenian, Danish, Somali, Greenland, Turkish and Chinese) showed that the Slovenian population grouped with the Danish population. The mean power of discrimination for the Slovenian population was 1.1 × 10-19, and the mean exclusion probability for trios was 99.96%.",

author = "Katja Drobnic and Claus B{\o}rsting and Eszter Rockenbauer and Carmen Tomas and Niels Morling",

year = "2010",

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language = "English",

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journal = "Forensic Science International: Genetics",

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TY - JOUR

T1 - Typing of 49 autosomal SNPs by SNaPshot in the Slovenian population

AU - Drobnic, Katja

AU - Børsting, Claus

AU - Rockenbauer, Eszter

AU - Tomas, Carmen

AU - Morling, Niels

PY - 2010/10

Y1 - 2010/10

N2 - A total of 157 unrelated individuals residing in Slovenia were typed for 49 of the autosomal single nucleotide polymorphisms (SNPs) in the SNPforID 52plex with the SNaPshot® assay. We obtained full SNP profiles in all but one individual and perfect concordance was obtained in duplicated analyses. Allele frequencies are presented for the 49 SNPs. No deviation from HWE was observed for any SNP. FIS and FST were estimated. A principal coordinate analysis performed on six populations (Slovenian, Danish, Somali, Greenland, Turkish and Chinese) showed that the Slovenian population grouped with the Danish population. The mean power of discrimination for the Slovenian population was 1.1 × 10-19, and the mean exclusion probability for trios was 99.96%.

AB - A total of 157 unrelated individuals residing in Slovenia were typed for 49 of the autosomal single nucleotide polymorphisms (SNPs) in the SNPforID 52plex with the SNaPshot® assay. We obtained full SNP profiles in all but one individual and perfect concordance was obtained in duplicated analyses. Allele frequencies are presented for the 49 SNPs. No deviation from HWE was observed for any SNP. FIS and FST were estimated. A principal coordinate analysis performed on six populations (Slovenian, Danish, Somali, Greenland, Turkish and Chinese) showed that the Slovenian population grouped with the Danish population. The mean power of discrimination for the Slovenian population was 1.1 × 10-19, and the mean exclusion probability for trios was 99.96%.

U2 - 10.1016/j.fsigen.2010.01.014

DO - 10.1016/j.fsigen.2010.01.014

M3 - Journal article

C2 - 20457083

SN - 1872-4973

VL - 4

SP - e125-7

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

IS - 5

ER -

Typing of 49 autosomal SNPs by SNaPshot in the Slovenian population

Abstract

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