Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond

Vibe Hallundbæk Østergaard; Michael Lisby

doi:10.1007/s00412-016-0617-2

Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond

Vibe Hallundbæk Østergaard^*, Michael Lisby

^*Corresponding author for this work

Functional Genomics

10 Citations (Scopus)

Abstract

Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.

Original language	English
Journal	Chromosoma
Volume	126
Issue number	2
Pages (from-to)	213-222
Number of pages	10
ISSN	0009-5915
DOIs	https://doi.org/10.1007/s00412-016-0617-2
Publication status	Published - 1 Mar 2017

Keywords

Anaphase bridges
Chromosomal fragile sites
Mitosis
Replication
Template switching
Transcription

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10.1007/s00412-016-0617-2

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abstract = "Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.",

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N2 - Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.

AB - Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.

KW - Anaphase bridges

KW - Chromosomal fragile sites

KW - Mitosis

KW - Replication

KW - Template switching

KW - Transcription

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JO - Chromosoma

JF - Chromosoma

IS - 2

ER -

Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond

Abstract

Keywords

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