Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond

Vibe Hallundbæk Østergaard; Michael Lisby

doi:10.1007/s00412-016-0617-2

Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond

Vibe Hallundbæk Østergaard^*, Michael Lisby

^*Corresponding author af dette arbejde

Functional genomics

10 Citationer (Scopus)

Abstract

Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.

Originalsprog	Engelsk
Tidsskrift	Chromosoma
Vol/bind	126
Udgave nummer	2
Sider (fra-til)	213-222
Antal sider	10
ISSN	0009-5915
DOI	https://doi.org/10.1007/s00412-016-0617-2
Status	Udgivet - 1 mar. 2017

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keywords = "Anaphase bridges, Chromosomal fragile sites, Mitosis, Replication, Template switching, Transcription",

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AU - Østergaard, Vibe Hallundbæk

AU - Lisby, Michael

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N2 - Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.

AB - Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.

KW - Anaphase bridges

KW - Chromosomal fragile sites

KW - Mitosis

KW - Replication

KW - Template switching

KW - Transcription

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M3 - Review

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SN - 0009-5915

VL - 126

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EP - 222

JO - Chromosoma

JF - Chromosoma

IS - 2

ER -

Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond

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