TY - JOUR
T1 - Thromboelastography-guided transfusion in dogs with hypocoagulable disorders
T2 - A case series
AU - Langhorn, Rebecca
AU - Bochsen, Louise
AU - Willesen, Jakob Lundgreen
AU - Sørensen, Tina Møller
AU - Kristensen, Annemarie Thuri
PY - 2019
Y1 - 2019
N2 - Background: Thromboelastography (TEG) is a global whole blood hemostasis assay which includes plasma as well as cellular components of hemostasis in the analysis and follows the quality and dynamics of clot development, stabilization, and lysis. In human medicine TEG is also a valuable asset in the therapeutic setting, allowing evaluation of the effect of transfusion therapy in vitro. This case series describes the use of TEG as a guiding tool for transfusion therapy in four dogs with hypocoagulable hemostatic disorders. Case presentation: Four dogs presented with hypocoagulable disorders of hemostasis, diagnosed as rodenticide intoxication, angiostrongylosis, disseminated intravascular coagulation following severe systemic inflammation, and immune-mediated thrombocytopenia, respectively. TEG was used as a diagnostic tool as well as a guiding tool in the decision of whether or not, and in what dose, fresh frozen plasma would be of benefit in the treatment protocol for each dog. Conclusions: TEG may be applied in the therapeutic setting as a means to tailor individual patient transfusion therapy in critically ill dogs with hypocoagulable states.
AB - Background: Thromboelastography (TEG) is a global whole blood hemostasis assay which includes plasma as well as cellular components of hemostasis in the analysis and follows the quality and dynamics of clot development, stabilization, and lysis. In human medicine TEG is also a valuable asset in the therapeutic setting, allowing evaluation of the effect of transfusion therapy in vitro. This case series describes the use of TEG as a guiding tool for transfusion therapy in four dogs with hypocoagulable hemostatic disorders. Case presentation: Four dogs presented with hypocoagulable disorders of hemostasis, diagnosed as rodenticide intoxication, angiostrongylosis, disseminated intravascular coagulation following severe systemic inflammation, and immune-mediated thrombocytopenia, respectively. TEG was used as a diagnostic tool as well as a guiding tool in the decision of whether or not, and in what dose, fresh frozen plasma would be of benefit in the treatment protocol for each dog. Conclusions: TEG may be applied in the therapeutic setting as a means to tailor individual patient transfusion therapy in critically ill dogs with hypocoagulable states.
KW - Bleeding
KW - Dog
KW - Hemostasis
KW - Thromboelastography
KW - Transfusion medicine
U2 - 10.1186/s13028-019-0469-x
DO - 10.1186/s13028-019-0469-x
M3 - Journal article
C2 - 31331398
AN - SCOPUS:85069781165
SN - 0044-605X
VL - 61
JO - Acta Veterinaria Scandinavica
JF - Acta Veterinaria Scandinavica
IS - 1
M1 - 35
ER -
