The retinoblastoma protein: multitasking to suppress tumorigenesis

Tinke L.  Vormer; Jacob B. Hansen; Hein te  Riele

doi:10.4161/23723548.2014.968062

The retinoblastoma protein: multitasking to suppress tumorigenesis

Tinke L. Vormer, Jacob B. Hansen, Hein te Riele

Cell Biology and Physiology

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Abstract

Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.

Original language	English
Article number	e968062-1
Journal	Molecular & Cellular Oncology
Volume	2
Issue number	1
Number of pages	2
ISSN	2372-3556
DOIs	https://doi.org/10.4161/23723548.2014.968062
Publication status	Published - 2 Jan 2015

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title = "The retinoblastoma protein: multitasking to suppress tumorigenesis",

abstract = "Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.",

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AB - Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.

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DO - 10.4161/23723548.2014.968062

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The retinoblastoma protein: multitasking to suppress tumorigenesis

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