Research output per year
Research output per year
Personal profile
CV
Jacob B. Hansen, Ph.D.
Jacob B. Hansen joined the Faculty of Health Sciences in February 2005. Before that he carried out 3-4 years of postdoctoral training at the Netherlands Cancer Institute in Amsterdam working mainly on directed differentiation of gene-targeted embryonic stem cells. Jacob obtained his Ph.D. in molecular biology from the University of Southern Denmark in 2001. His Ph.D. project dealt with functions of peroxisome proliferator-activated receptors and the retinoblastoma protein in fat cell (adipocyte) differentiation. His work at the Department of Biomedical Sciences focuses on identification of novel molecular determinants regulating white versus brown adipocyte differentiation as well as factors contributing to mitochondrial respiration and biogenesis during adipose conversion.
Education and employment
May 2011-present
Associate professor at the Department of Biomedical Sciences, the Panum Institute, University of Copenhagen.
February 2007-April 2011
Assistant professor at the Department of Biomedical Sciences, the Panum Institute, University of Copenhagen.
February 2005-January 2007
Research assistant professor in the Diabetes and Stem Cell Group at the Department of Medical Biochemistry and Genetics, the Panum Institute, University of Copenhagen.
Supported by the Carlsberg Foundation.
November 2004-January 2005:
Research assistant professor at the Department of Biochemistry and Molecular Biology, University of Southern Denmark.
April 2001-September 2004:
Postdoctoral fellow at the Netherlands Cancer Institute, Amsterdam.
Supervisor: Hein te Riele, professor, Ph.D., head of division.
Supported by fellowships from the Federation of European Biochemical Societies and the Dutch Cancer Society.
October 1996-March 2001:
Ph.D. studies at the Department of Biochemistry and Molecular Biology, University of Southern Denmark.
Supervisor: Karsten Kristiansen, professor.
Title of Ph.D. thesis: Regulation of adipogenesis by the retinoblastoma protein and peroxisome proliferator-activated receptors. Ph.D. awarded in March 2001.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
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Pannexin-1 mediated ATP release in adipocytes is sensitive to glucose and insulin and modulates lipolysis and macrophage migration
Tozzi, M., Hansen, J. B. & Novak, I., 1 Feb 2020, In: Acta Physiologica. 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Overexpression of cyclooxygenase-2 in adipocytes reduces fat accumulation in inguinal white adipose tissue and hepatic steatosis in high-fat fed mice
Danneskiold-Samsøe, N. B., Sonne, S. B., Larsen, J. M., Hansen, A. N., Fjære, E., Isidor, M. S., Petersen, S., Henningsen, J., Severi, I., Sartini, L., Schobers, Y., Wolf, J., Nockhers, W. A., Wolfrum, C., Cinti, S., Sina, C., Hansen, J. B., Madsen, L., Brix, S. & Kristiansen, K., 1 Dec 2019, In: Scientific Reports. 9, 13 p., 8979.Research output: Contribution to journal › Journal article › Research › peer-review
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Possible link between FSH and RANKL release from adipocytes in men with impaired gonadal function including Klinefelter syndrome
Mortensen, L. J., Lorenzen, M., Jørgensen, N., Andersson, A.-M., Nielsen, J. E., Petersen, L. I., Lanske, B., Juul, A., Hansen, J. B. & Jensen, M. B., Jun 2019, In: Bone. 123, p. 103-114Research output: Contribution to journal › Journal article › Research › peer-review
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GSK3 is a negative regulator of the thermogenic program in brown adipocytes
Markussen, L. K., Winther, S., Wicksteed, B. & Hansen, J. B., 1 Dec 2018, In: Scientific Reports. 8, p. 1-12 3469.Research output: Contribution to journal › Journal article › Research › peer-review
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Metformin targets brown adipose tissue in vivo and reduces oxygen consumption in vitro
Breining, P., Jensen, J. B., Sundelin, E. I., Gormsen, L. C., Jakobsen, S., Busk, M., Rolighed, L., Bross, P., Fernandez-Guerra, P., Markussen, L. K., Rasmussen, N. E., Hansen, J. B., Pedersen, S. B., Richelsen, B. & Jessen, N., Sept 2018, In: Diabetes, Obesity and Metabolism. 20, 9, p. 2264-2273Research output: Contribution to journal › Journal article › Research › peer-review
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Restricting glycolysis impairs brown adipocyte glucose and oxygen consumption
Winther, S., Isidor, M. S., Basse, A. L., Skjoldborg, N., Cheung, A., Quistorff, B. & Hansen, J. B., Mar 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 314, 3, p. E214-E223 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor
Markussen, L. K., Isidor, M. S., Breining, P., Andersen, E. S., Rasmussen, N. E., Petersen, L. I., Pedersen, S. B., Richelsen, B. & Hansen, J. B., 28 Sept 2017, In: PLoS ONE. 12, 9, 17 p., e0185624.Research output: Contribution to journal › Journal article › Research › peer-review
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MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism
Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, M. S., Markussen, L. K., Viuff, B. M., Lambert, I. H., Hansen, J. B. & Pedersen, S. H. F., 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.Research output: Contribution to journal › Journal article › Research › peer-review