The retinoblastoma protein: multitasking to suppress tumorigenesis

Tinke L.  Vormer; Jacob B. Hansen; Hein te  Riele

doi:10.4161/23723548.2014.968062

The retinoblastoma protein: multitasking to suppress tumorigenesis

Tinke L. Vormer, Jacob B. Hansen, Hein te Riele

Cellebiologi og Fysiologi

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Abstract

Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.

Originalsprog	Engelsk
Artikelnummer	e968062-1
Tidsskrift	Molecular & Cellular Oncology
Vol/bind	2
Udgave nummer	1
Antal sider	2
ISSN	2372-3556
DOI	https://doi.org/10.4161/23723548.2014.968062
Status	Udgivet - 2 jan. 2015

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10.4161/23723548.2014.968062

The retinoblastoma proteinForlagets udgivne version, 1,54 MB

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title = "The retinoblastoma protein: multitasking to suppress tumorigenesis",

abstract = "Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.",

author = "Vormer, {Tinke L.} and Hansen, {Jacob B.} and Riele, {Hein te}",

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AB - Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.

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DO - 10.4161/23723548.2014.968062

M3 - Journal article

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JO - Molecular & Cellular Oncology

JF - Molecular & Cellular Oncology

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The retinoblastoma protein: multitasking to suppress tumorigenesis

Abstract

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