Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

Niels Grarup; Mette K Andersen; Camilla H Andreasen; Anders Albrechtsen; Knut Borch-Johnsen; Torben Jørgensen; Johan Auwerx; Ole Schmitz; Torben Hansen; Oluf Pedersen

doi:10.1210/jc.2006-1958

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

Niels Grarup, Mette K Andersen, Camilla H Andreasen, Anders Albrechtsen, Knut Borch-Johnsen, Torben Jørgensen, Johan Auwerx, Ole Schmitz, Torben Hansen, Oluf Pedersen

41 Citations (Scopus)

Abstract

The type 2 iodothyronine deiodinase (D2) catalyzes the conversion of T(4) to the active form of thyroid hormone, which is a critical regulator of thermogenesis and glucose metabolism. A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	92
Issue number	1
Pages (from-to)	363-6
Number of pages	4
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2006-1958
Publication status	Published - 2007

Keywords

Adult
Cohort Studies
Diabetes Mellitus, Type 2
European Continental Ancestry Group
Female
Humans
Insulin Resistance
Iodide Peroxidase
Male
Middle Aged
Obesity
Phenotype
Polymorphism, Genetic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jc.2006-1958

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abstract = "The type 2 iodothyronine deiodinase (D2) catalyzes the conversion of T(4) to the active form of thyroid hormone, which is a critical regulator of thermogenesis and glucose metabolism. A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance.",

keywords = "Adult, Cohort Studies, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Humans, Insulin Resistance, Iodide Peroxidase, Male, Middle Aged, Obesity, Phenotype, Polymorphism, Genetic",

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journal = "Journal of Clinical Endocrinology and Metabolism",

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T1 - Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

AU - Grarup, Niels

AU - Andersen, Mette K

AU - Andreasen, Camilla H

AU - Albrechtsen, Anders

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Auwerx, Johan

AU - Schmitz, Ole

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2007

Y1 - 2007

N2 - The type 2 iodothyronine deiodinase (D2) catalyzes the conversion of T(4) to the active form of thyroid hormone, which is a critical regulator of thermogenesis and glucose metabolism. A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance.

AB - The type 2 iodothyronine deiodinase (D2) catalyzes the conversion of T(4) to the active form of thyroid hormone, which is a critical regulator of thermogenesis and glucose metabolism. A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance.

KW - Adult

KW - Cohort Studies

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Female

KW - Humans

KW - Insulin Resistance

KW - Iodide Peroxidase

KW - Male

KW - Middle Aged

KW - Obesity

KW - Phenotype

KW - Polymorphism, Genetic

U2 - 10.1210/jc.2006-1958

DO - 10.1210/jc.2006-1958

M3 - Journal article

C2 - 17077128

SN - 0021-972X

VL - 92

SP - 363

EP - 366

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 1

ER -

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

Abstract

Keywords

UN SDGs

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