Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects

A P Gjesing; G Andersen; A Albrechtsen; C Glümer; K Borch-Johnsen; T Jørgensen; T Hansen; O Pedersen

doi:10.1111/j.1464-5491.2006.02031.x

Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects

A P Gjesing, G Andersen, A Albrechtsen, C Glümer, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen

28 Citations (Scopus)

Abstract

Activation of the beta(1)-adrenergic receptor (ADRB1) causes increased lipolysis in adipose tissue and enhances cardiac output. Analysis of the association of the functional ADRB1 Arg389Gly variant with obesity and hypertension has given ambiguous results. To clarify the potential impact of this variant on obesity and hypertension in the general population, we examined the Arg389Gly variant in a relatively large-scale population-based study.

Original language	English
Journal	Diabetic Medicine
Volume	24
Issue number	4
Pages (from-to)	392-7
Number of pages	6
ISSN	0742-3071
DOIs	https://doi.org/10.1111/j.1464-5491.2006.02031.x
Publication status	Published - Apr 2007

Keywords

Adult
Aged
Alleles
Denmark
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Epidemiologic Studies
Female
Genotype
Humans
Hypertension
Male
Middle Aged
Obesity
Polymorphism, Genetic
Receptors, Adrenergic, beta-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1464-5491.2006.02031.x

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Gjesing, A. P., Andersen, G., Albrechtsen, A., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Hansen, T., & Pedersen, O. (2007). Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects. Diabetic Medicine, 24(4), 392-7. https://doi.org/10.1111/j.1464-5491.2006.02031.x

Gjesing, AP, Andersen, G, Albrechtsen, A, Glümer, C, Borch-Johnsen, K, Jørgensen, T, Hansen, T & Pedersen, O 2007, 'Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects', Diabetic Medicine, vol. 24, no. 4, pp. 392-7. https://doi.org/10.1111/j.1464-5491.2006.02031.x

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AU - Glümer, C

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Hansen, T

AU - Pedersen, O

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AB - Activation of the beta(1)-adrenergic receptor (ADRB1) causes increased lipolysis in adipose tissue and enhances cardiac output. Analysis of the association of the functional ADRB1 Arg389Gly variant with obesity and hypertension has given ambiguous results. To clarify the potential impact of this variant on obesity and hypertension in the general population, we examined the Arg389Gly variant in a relatively large-scale population-based study.

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KW - Aged

KW - Alleles

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KW - Diabetes Mellitus, Type 2

KW - Diabetic Angiopathies

KW - Epidemiologic Studies

KW - Female

KW - Genotype

KW - Humans

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Obesity

KW - Polymorphism, Genetic

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VL - 24

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JO - Diabetic Medicine

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IS - 4

ER -

Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects

Abstract

Keywords

UN SDGs

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