Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects

TY - JOUR

T1 - Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects

AU - Gjesing, A P

AU - Andersen, G

AU - Albrechtsen, A

AU - Glümer, C

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Hansen, T

AU - Pedersen, O

PY - 2007/4

Y1 - 2007/4

N2 - Activation of the beta(1)-adrenergic receptor (ADRB1) causes increased lipolysis in adipose tissue and enhances cardiac output. Analysis of the association of the functional ADRB1 Arg389Gly variant with obesity and hypertension has given ambiguous results. To clarify the potential impact of this variant on obesity and hypertension in the general population, we examined the Arg389Gly variant in a relatively large-scale population-based study.

AB - Activation of the beta(1)-adrenergic receptor (ADRB1) causes increased lipolysis in adipose tissue and enhances cardiac output. Analysis of the association of the functional ADRB1 Arg389Gly variant with obesity and hypertension has given ambiguous results. To clarify the potential impact of this variant on obesity and hypertension in the general population, we examined the Arg389Gly variant in a relatively large-scale population-based study.

KW - Adult

KW - Aged

KW - Alleles

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Diabetic Angiopathies

KW - Epidemiologic Studies

KW - Female

KW - Genotype

KW - Humans

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Obesity

KW - Polymorphism, Genetic

KW - Receptors, Adrenergic, beta-1

U2 - 10.1111/j.1464-5491.2006.02031.x

DO - 10.1111/j.1464-5491.2006.02031.x

M3 - Journal article

C2 - 17335470

SN - 0742-3071

VL - 24

SP - 392

EP - 397

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 4

ER -