Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies

Niels Grarup; Chrisian S Rose; Ehm A Andersson; Gitte Andersen; Arne L Nielsen; Anders Albrechtsen; Jesper O Clausen; Signe S Rasmussen; Torben Jørgensen; Annelli Sandbaek; Torsten Lauritzen; Ole Schmitz; Torben Hansen; Oluf Pedersen

doi:10.2337/db07-0856

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies

Niels Grarup, Chrisian S Rose, Ehm A Andersson, Gitte Andersen, Arne L Nielsen, Anders Albrechtsen, Jesper O Clausen, Signe S Rasmussen, Torben Jørgensen, Annelli Sandbaek, Torsten Lauritzen, Ole Schmitz, Torben Hansen, Oluf Pedersen

195 Citations (Scopus)

Abstract

In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants.

Original language	English
Journal	Diabetes
Volume	56
Issue number	12
Pages (from-to)	3105-11
Number of pages	7
ISSN	0046-0192
DOIs	https://doi.org/10.2337/db07-0856
Publication status	Published - 2007

Keywords

Adult
Cohort Studies
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Denmark
Diabetes Mellitus, Type 2
European Continental Ancestry Group
Genetic Predisposition to Disease
Genetic Variation
Genome, Human
Glucose Intolerance
Homeodomain Proteins
Humans
Insulin
Insulin-Like Growth Factor Binding Protein 2
Introns
Middle Aged
Reference Values
Reproducibility of Results
Transcription Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Grarup, N., Rose, C. S., Andersson, E. A., Andersen, G., Nielsen, A. L., Albrechtsen, A., Clausen, J. O., Rasmussen, S. S., Jørgensen, T., Sandbaek, A., Lauritzen, T., Schmitz, O., Hansen, T., & Pedersen, O. (2007). Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes, 56(12), 3105-11. https://doi.org/10.2337/db07-0856

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects : validation and extension of genome-wide association studies. / Grarup, Niels; Rose, Chrisian S; Andersson, Ehm A et al.

In: Diabetes, Vol. 56, No. 12, 2007, p. 3105-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Grarup, N, Rose, CS, Andersson, EA, Andersen, G, Nielsen, AL, Albrechtsen, A, Clausen, JO, Rasmussen, SS, Jørgensen, T, Sandbaek, A, Lauritzen, T, Schmitz, O, Hansen, T & Pedersen, O 2007, 'Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies', Diabetes, vol. 56, no. 12, pp. 3105-11. https://doi.org/10.2337/db07-0856

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abstract = "In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants.",

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AU - Grarup, Niels

AU - Rose, Chrisian S

AU - Andersson, Ehm A

AU - Andersen, Gitte

AU - Nielsen, Arne L

AU - Albrechtsen, Anders

AU - Clausen, Jesper O

AU - Rasmussen, Signe S

AU - Jørgensen, Torben

AU - Sandbaek, Annelli

AU - Lauritzen, Torsten

AU - Schmitz, Ole

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2007

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AB - In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants.

KW - Adult

KW - Cohort Studies

KW - Cyclin-Dependent Kinase Inhibitor p15

KW - Cyclin-Dependent Kinase Inhibitor p16

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genome, Human

KW - Glucose Intolerance

KW - Homeodomain Proteins

KW - Humans

KW - Insulin

KW - Insulin-Like Growth Factor Binding Protein 2

KW - Introns

KW - Middle Aged

KW - Reference Values

KW - Reproducibility of Results

KW - Transcription Factors

U2 - 10.2337/db07-0856

DO - 10.2337/db07-0856

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SN - 0012-1797

VL - 56

SP - 3105

EP - 3111

JO - Diabetes

JF - Diabetes

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ER -