Structural variations of staphylococcal cassette chromosome mec Type IVa in Staphylococcus aureus clonal complex 8 and unrelated lineages

Peter Panduro Damborg; Mette Damkjær Bartels; Kit Boye; Luca Guardabassi; Henrik T. Westh

doi:10.1128/AAC.00012-11

Structural variations of staphylococcal cassette chromosome mec Type IVa in Staphylococcus aureus clonal complex 8 and unrelated lineages

Peter Panduro Damborg, Mette Damkjær Bartels, Kit Boye, Luca Guardabassi, Henrik T. Westh

7 Citations (Scopus)

Abstract

PCR mapping of staphylococcal cassette chromosome mec type IVa and adjacent mobile elements in 94 methicillin-resistant Staphylococcus aureus (MRSA) strains identified two primary structures (A and B) that could be further classified into two (A1 and A2) and five (B1 to B5) variants, primarily based on structural differences in the orfX-J3 region. While spa type t008 (USA300) invariably contained the A variants, other spa types belonging to clonal complex 8 and unrelated lineages generally contained B variants. These findings have important implications for the typing and identification of MRSA strains containing B variants.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	8
Pages (from-to)	3932-3935
Number of pages	4
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.00012-11
Publication status	Published - Aug 2011

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Structural variations of staphylococcal cassette chromosome mec Type IVa in Staphylococcus aureus clonal complex 8 and unrelated lineagesFinal published version, 1.23 MB

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Structural variations of staphylococcal cassette chromosome mec Type IVa in Staphylococcus aureus clonal complex 8 and unrelated lineages. / Damborg, Peter Panduro; Bartels, Mette Damkjær; Boye, Kit et al.

In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 8, 08.2011, p. 3932-3935.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Westh, Henrik T.

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Structural variations of staphylococcal cassette chromosome mec Type IVa in Staphylococcus aureus clonal complex 8 and unrelated lineages

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