Stimulation in primary MLR caused by a PLT defined non-HLA-D/DR determinant, EP1

W Holter; N Morling

Stimulation in primary MLR caused by a PLT defined non-HLA-D/DR determinant, EP1

Abstract

The influence in primary mixed lymphocyte culture reaction (MLR) of a primed lymphocyte typing (PLT) defined non-HLA-D/DR determinant, EP1, was investigated. In primary MLR between HLA-D/DR compatible lymphocytes, the response of the lymphocytes from 14 EP1-negative HLA-D/DR heterozygous individuals towards two EP1-positive homozygous typing cells (HTCs) was on an average approximately 35% higher than the response towards two EP1-negative HTCs (P less than 0.01). The strength of the MLR between lymphocytes from 25 EP1-negative and 10 EP1-positive individuals matched for two HLA-D/DR antigens was investigated. The average responses of EP1-negative lymphocytes against EP1-positive lymphocytes were approximately 40% higher than the average responses against EP1-negative lymphocytes (P less than 0.01). These data indicate that the PLT defined determinant EP1 causes stimulation in primary MLR.

Original language	English
Journal	HLA
Volume	22
Issue number	1
Pages (from-to)	42-8
Number of pages	6
ISSN	2059-2302
Publication status	Published - 1983
Externally published	Yes

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@article{89d198c0328811df8ed1000ea68e967b,

title = "Stimulation in primary MLR caused by a PLT defined non-HLA-D/DR determinant, EP1",

abstract = "The influence in primary mixed lymphocyte culture reaction (MLR) of a primed lymphocyte typing (PLT) defined non-HLA-D/DR determinant, EP1, was investigated. In primary MLR between HLA-D/DR compatible lymphocytes, the response of the lymphocytes from 14 EP1-negative HLA-D/DR heterozygous individuals towards two EP1-positive homozygous typing cells (HTCs) was on an average approximately 35% higher than the response towards two EP1-negative HTCs (P less than 0.01). The strength of the MLR between lymphocytes from 25 EP1-negative and 10 EP1-positive individuals matched for two HLA-D/DR antigens was investigated. The average responses of EP1-negative lymphocytes against EP1-positive lymphocytes were approximately 40% higher than the average responses against EP1-negative lymphocytes (P less than 0.01). These data indicate that the PLT defined determinant EP1 causes stimulation in primary MLR.",

author = "W Holter and N Morling",

note = "Keywords: Epitopes; HLA-DR Antigens; Histocompatibility Antigens Class II; Humans; Isoantigens; Lymphocyte Activation; Lymphocyte Culture Test, Mixed",

year = "1983",

language = "English",

volume = "22",

pages = "42--8",

journal = "HLA",

issn = "2059-2302",

publisher = "Wiley",

number = "1",

}

TY - JOUR

T1 - Stimulation in primary MLR caused by a PLT defined non-HLA-D/DR determinant, EP1

AU - Holter, W

AU - Morling, N

N1 - Keywords: Epitopes; HLA-DR Antigens; Histocompatibility Antigens Class II; Humans; Isoantigens; Lymphocyte Activation; Lymphocyte Culture Test, Mixed

PY - 1983

Y1 - 1983

N2 - The influence in primary mixed lymphocyte culture reaction (MLR) of a primed lymphocyte typing (PLT) defined non-HLA-D/DR determinant, EP1, was investigated. In primary MLR between HLA-D/DR compatible lymphocytes, the response of the lymphocytes from 14 EP1-negative HLA-D/DR heterozygous individuals towards two EP1-positive homozygous typing cells (HTCs) was on an average approximately 35% higher than the response towards two EP1-negative HTCs (P less than 0.01). The strength of the MLR between lymphocytes from 25 EP1-negative and 10 EP1-positive individuals matched for two HLA-D/DR antigens was investigated. The average responses of EP1-negative lymphocytes against EP1-positive lymphocytes were approximately 40% higher than the average responses against EP1-negative lymphocytes (P less than 0.01). These data indicate that the PLT defined determinant EP1 causes stimulation in primary MLR.

AB - The influence in primary mixed lymphocyte culture reaction (MLR) of a primed lymphocyte typing (PLT) defined non-HLA-D/DR determinant, EP1, was investigated. In primary MLR between HLA-D/DR compatible lymphocytes, the response of the lymphocytes from 14 EP1-negative HLA-D/DR heterozygous individuals towards two EP1-positive homozygous typing cells (HTCs) was on an average approximately 35% higher than the response towards two EP1-negative HTCs (P less than 0.01). The strength of the MLR between lymphocytes from 25 EP1-negative and 10 EP1-positive individuals matched for two HLA-D/DR antigens was investigated. The average responses of EP1-negative lymphocytes against EP1-positive lymphocytes were approximately 40% higher than the average responses against EP1-negative lymphocytes (P less than 0.01). These data indicate that the PLT defined determinant EP1 causes stimulation in primary MLR.

M3 - Journal article

C2 - 6193606

SN - 2059-2302

VL - 22

SP - 42

EP - 48

JO - HLA

JF - HLA

IS - 1

ER -

Stimulation in primary MLR caused by a PLT defined non-HLA-D/DR determinant, EP1

Abstract

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