@article{89d198c0328811df8ed1000ea68e967b,
title = "Stimulation in primary MLR caused by a PLT defined non-HLA-D/DR determinant, EP1",
abstract = "The influence in primary mixed lymphocyte culture reaction (MLR) of a primed lymphocyte typing (PLT) defined non-HLA-D/DR determinant, EP1, was investigated. In primary MLR between HLA-D/DR compatible lymphocytes, the response of the lymphocytes from 14 EP1-negative HLA-D/DR heterozygous individuals towards two EP1-positive homozygous typing cells (HTCs) was on an average approximately 35% higher than the response towards two EP1-negative HTCs (P less than 0.01). The strength of the MLR between lymphocytes from 25 EP1-negative and 10 EP1-positive individuals matched for two HLA-D/DR antigens was investigated. The average responses of EP1-negative lymphocytes against EP1-positive lymphocytes were approximately 40% higher than the average responses against EP1-negative lymphocytes (P less than 0.01). These data indicate that the PLT defined determinant EP1 causes stimulation in primary MLR.",
author = "W Holter and N Morling",
note = "Keywords: Epitopes; HLA-DR Antigens; Histocompatibility Antigens Class II; Humans; Isoantigens; Lymphocyte Activation; Lymphocyte Culture Test, Mixed",
year = "1983",
language = "English",
volume = "22",
pages = "42--8",
journal = "HLA",
issn = "2059-2302",
publisher = "Wiley",
number = "1",
}