RNF138 joins the HR team

Simon Bekker-Jensen; Niels Mailand

doi:10.1038/ncb3262

RNF138 joins the HR team

2 Citationer (Scopus)

Abstract

Two studies show that the E3 ubiquitin ligase RNF138 is recruited to DNA double-strand break sites, where it ubiquitylates key repair factors to promote DNA-end resection and homologous recombination. These findings add insights into the multilayered regulatory mechanisms underlying DNA double-strand break repair pathway choice in mammalian cells.

Originalsprog	Engelsk
Tidsskrift	Nature Cell Biology
Vol/bind	17
Udgave nummer	11
Sider (fra-til)	1375-7
Antal sider	3
ISSN	1465-7392
DOI	https://doi.org/10.1038/ncb3262
Status	Udgivet - 1 nov. 2015

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10.1038/ncb3262

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RNF138 joins the HR team

Abstract

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