Richness of human gut microbiome correlates with metabolic markers

Emmanuelle Le Chatelier; Trine Nielsen; Junjie Qin; Edi Prifti; Falk Hildebrand; Gwen Falony; Mathieu Almeida; Manimozhiyan Arumugam; Jean-Michel Batto; Sean Kennedy; Pierre Leonard; Junhua Li; Kristoffer Sølvsten Burgdorf; Niels Grarup; Torben Jørgensen; Ivan Brandslund; Henrik Bjørn Nielsen; Agnieszka Juncker; Marcelo Bertalan Quintanilha dos Santos; Florence Levenez; Nicolas Pons; Simon Rasmussen; Shinichi Sunagawa; Julien Tap; Sebastian Tims; Erwin G Zoetendal; Søren Brunak; Karine Clément; Joël Doré; Michiel Kleerebezem; Karsten Kristiansen; Pierre Renault; Thomas Sicheritz-Ponten; Willem M de Vos; Jean-Daniel Zucker; Jeroen Raes; Torben Hansen; Peer Bork; Jun Wang; S Dusko Ehrlich; Oluf Borbye Pedersen; Eric Guedon; Christine Delorme; Séverine Layec; Ghalia Khaci; Maarten van de Guchte; Gaetana Vandemeulebrouck; Alexandre Jamet; Rozenn Dervyn; Nicolas Sanchez; Emmanuelle Maguin; Florence Haimet; Yohanan Winogradski; Antonella Cultrone; Marion Leclerc; Catherine Juste; Hervé Blottière; Eric Pelletier; Denis LePaslier; François Artiguenave; Thomas Bruls; Jean Weissenbach; Keith Turner; Julian Parkhill; Maria Antolin; Chaysavanh Manichanh; Francesc Casellas; Natalia Boruel; Encarna Varela; Antonio Torrejon; Francisco Guarner; Gérard Denariaz; Muriel Derrien; Johan E T van Hylckama Vlieg; Patrick Veiga; Raish Oozeer; Jan Knol; Maria Rescigno; Christian Brechot; Alexandre Mérieux; Christine M'Rini; Takuji Yamada

doi:10.1038/nature12506

Richness of human gut microbiome correlates with metabolic markers

Emmanuelle Le Chatelier, Trine Nielsen, Junjie Qin, Edi Prifti, Falk Hildebrand, Gwen Falony, Mathieu Almeida, Manimozhiyan Arumugam, Jean-Michel Batto, Sean Kennedy, Pierre Leonard, Junhua Li, Kristoffer Sølvsten Burgdorf, Niels Grarup, Torben Jørgensen, Ivan Brandslund, Henrik Bjørn Nielsen, Agnieszka Juncker, Marcelo Bertalan Quintanilha dos Santos, Florence LevenezNicolas Pons, Simon Rasmussen, Shinichi Sunagawa, Julien Tap, Sebastian Tims, Erwin G Zoetendal, Søren Brunak, Karine Clément, Joël Doré, Michiel Kleerebezem, Karsten Kristiansen, Pierre Renault, Thomas Sicheritz-Ponten, Willem M de Vos, Jean-Daniel Zucker, Jeroen Raes, Torben Hansen, Peer Bork, Jun Wang, S Dusko Ehrlich, Oluf Borbye Pedersen, Eric Guedon, Christine Delorme, Séverine Layec, Ghalia Khaci, Maarten van de Guchte, Gaetana Vandemeulebrouck, Alexandre Jamet, Rozenn Dervyn, Nicolas Sanchez, Emmanuelle Maguin, Florence Haimet, Yohanan Winogradski, Antonella Cultrone, Marion Leclerc, Catherine Juste, Hervé Blottière, Eric Pelletier, Denis LePaslier, François Artiguenave, Thomas Bruls, Jean Weissenbach, Keith Turner, Julian Parkhill, Maria Antolin, Chaysavanh Manichanh, Francesc Casellas, Natalia Boruel, Encarna Varela, Antonio Torrejon, Francisco Guarner, Gérard Denariaz, Muriel Derrien, Johan E T van Hylckama Vlieg, Patrick Veiga, Raish Oozeer, Jan Knol, Maria Rescigno, Christian Brechot, Alexandre Mérieux, Christine M'Rini, Takuji Yamada

2055 Citations (Scopus)

Abstract

We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

Original language	English
Journal	Nature
Volume	500
Issue number	7464
Pages (from-to)	541-546
Number of pages	6
ISSN	0028-0836
DOIs	https://doi.org/10.1038/nature12506
Publication status	Published - 2013

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10.1038/nature12506

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Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., Leonard, P., Li, J., Burgdorf, K. S., Grarup, N., Jørgensen, T., Brandslund, I., Nielsen, H. B., Juncker, A., dos Santos, M. B. Q., ... Yamada, T. (2013). Richness of human gut microbiome correlates with metabolic markers. Nature, 500(7464), 541-546. https://doi.org/10.1038/nature12506

Le Chatelier, E, Nielsen, T, Qin, J, Prifti, E, Hildebrand, F, Falony, G, Almeida, M, Arumugam, M, Batto, J-M, Kennedy, S, Leonard, P, Li, J, Burgdorf, KS , Grarup, N, Jørgensen, T, Brandslund, I, Nielsen, HB, Juncker, A, dos Santos, MBQ, Levenez, F, Pons, N, Rasmussen, S, Sunagawa, S, Tap, J, Tims, S, Zoetendal, EG, Brunak, S, Clément, K, Doré, J, Kleerebezem, M, Kristiansen, K, Renault, P, Sicheritz-Ponten, T, de Vos, WM, Zucker, J-D, Raes, J, Hansen, T, Bork, P, Wang, J, Ehrlich, SD, Pedersen, OB, Guedon, E, Delorme, C, Layec, S, Khaci, G, van de Guchte, M, Vandemeulebrouck, G, Jamet, A, Dervyn, R, Sanchez, N, Maguin, E, Haimet, F, Winogradski, Y, Cultrone, A, Leclerc, M, Juste, C, Blottière, H, Pelletier, E, LePaslier, D, Artiguenave, F, Bruls, T, Weissenbach, J, Turner, K, Parkhill, J, Antolin, M, Manichanh, C, Casellas, F, Boruel, N, Varela, E, Torrejon, A, Guarner, F, Denariaz, G, Derrien, M, van Hylckama Vlieg, JET, Veiga, P, Oozeer, R, Knol, J, Rescigno, M, Brechot, C, Mérieux, A, M'Rini, C & Yamada, T 2013, 'Richness of human gut microbiome correlates with metabolic markers', Nature, vol. 500, no. 7464, pp. 541-546. https://doi.org/10.1038/nature12506

@article{3ac22222792e456e9c487251a2710717,

title = "Richness of human gut microbiome correlates with metabolic markers",

abstract = "We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.",

author = "{Le Chatelier}, Emmanuelle and Trine Nielsen and Junjie Qin and Edi Prifti and Falk Hildebrand and Gwen Falony and Mathieu Almeida and Manimozhiyan Arumugam and Jean-Michel Batto and Sean Kennedy and Pierre Leonard and Junhua Li and Burgdorf, {Kristoffer S{\o}lvsten} and Niels Grarup and Torben J{\o}rgensen and Ivan Brandslund and Nielsen, {Henrik Bj{\o}rn} and Agnieszka Juncker and {dos Santos}, {Marcelo Bertalan Quintanilha} and Florence Levenez and Nicolas Pons and Simon Rasmussen and Shinichi Sunagawa and Julien Tap and Sebastian Tims and Zoetendal, {Erwin G} and S{\o}ren Brunak and Karine Cl{\'e}ment and Jo{\"e}l Dor{\'e} and Michiel Kleerebezem and Karsten Kristiansen and Pierre Renault and Thomas Sicheritz-Ponten and {de Vos}, {Willem M} and Jean-Daniel Zucker and Jeroen Raes and Torben Hansen and Peer Bork and Jun Wang and Ehrlich, {S Dusko} and Pedersen, {Oluf Borbye} and Eric Guedon and Christine Delorme and S{\'e}verine Layec and Ghalia Khaci and {van de Guchte}, Maarten and Gaetana Vandemeulebrouck and Alexandre Jamet and Rozenn Dervyn and Nicolas Sanchez and Emmanuelle Maguin and Florence Haimet and Yohanan Winogradski and Antonella Cultrone and Marion Leclerc and Catherine Juste and Herv{\'e} Blotti{\`e}re and Eric Pelletier and Denis LePaslier and Fran{\c c}ois Artiguenave and Thomas Bruls and Jean Weissenbach and Keith Turner and Julian Parkhill and Maria Antolin and Chaysavanh Manichanh and Francesc Casellas and Natalia Boruel and Encarna Varela and Antonio Torrejon and Francisco Guarner and G{\'e}rard Denariaz and Muriel Derrien and {van Hylckama Vlieg}, {Johan E T} and Patrick Veiga and Raish Oozeer and Jan Knol and Maria Rescigno and Christian Brechot and Alexandre M{\'e}rieux and Christine M'Rini and Takuji Yamada",

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doi = "10.1038/nature12506",

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pages = "541--546",

journal = "Nature",

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T1 - Richness of human gut microbiome correlates with metabolic markers

AU - Le Chatelier, Emmanuelle

AU - Nielsen, Trine

AU - Qin, Junjie

AU - Prifti, Edi

AU - Hildebrand, Falk

AU - Falony, Gwen

AU - Almeida, Mathieu

AU - Arumugam, Manimozhiyan

AU - Batto, Jean-Michel

AU - Kennedy, Sean

AU - Leonard, Pierre

AU - Li, Junhua

AU - Burgdorf, Kristoffer Sølvsten

AU - Grarup, Niels

AU - Jørgensen, Torben

AU - Brandslund, Ivan

AU - Nielsen, Henrik Bjørn

AU - Juncker, Agnieszka

AU - dos Santos, Marcelo Bertalan Quintanilha

AU - Levenez, Florence

AU - Pons, Nicolas

AU - Rasmussen, Simon

AU - Sunagawa, Shinichi

AU - Tap, Julien

AU - Tims, Sebastian

AU - Zoetendal, Erwin G

AU - Brunak, Søren

AU - Clément, Karine

AU - Doré, Joël

AU - Kleerebezem, Michiel

AU - Kristiansen, Karsten

AU - Renault, Pierre

AU - Sicheritz-Ponten, Thomas

AU - de Vos, Willem M

AU - Zucker, Jean-Daniel

AU - Raes, Jeroen

AU - Hansen, Torben

AU - Bork, Peer

AU - Wang, Jun

AU - Ehrlich, S Dusko

AU - Pedersen, Oluf Borbye

AU - Guedon, Eric

AU - Delorme, Christine

AU - Layec, Séverine

AU - Khaci, Ghalia

AU - van de Guchte, Maarten

AU - Vandemeulebrouck, Gaetana

AU - Jamet, Alexandre

AU - Dervyn, Rozenn

AU - Sanchez, Nicolas

AU - Maguin, Emmanuelle

AU - Haimet, Florence

AU - Winogradski, Yohanan

AU - Cultrone, Antonella

AU - Leclerc, Marion

AU - Juste, Catherine

AU - Blottière, Hervé

AU - Pelletier, Eric

AU - LePaslier, Denis

AU - Artiguenave, François

AU - Bruls, Thomas

AU - Weissenbach, Jean

AU - Turner, Keith

AU - Parkhill, Julian

AU - Antolin, Maria

AU - Manichanh, Chaysavanh

AU - Casellas, Francesc

AU - Boruel, Natalia

AU - Varela, Encarna

AU - Torrejon, Antonio

AU - Guarner, Francisco

AU - Denariaz, Gérard

AU - Derrien, Muriel

AU - van Hylckama Vlieg, Johan E T

AU - Veiga, Patrick

AU - Oozeer, Raish

AU - Knol, Jan

AU - Rescigno, Maria

AU - Brechot, Christian

AU - Mérieux, Alexandre

AU - M'Rini, Christine

AU - Yamada, Takuji

PY - 2013

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N2 - We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

AB - We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

U2 - 10.1038/nature12506

DO - 10.1038/nature12506

M3 - Journal article

C2 - 23985870

SN - 0028-0836

VL - 500

SP - 541

EP - 546

JO - Nature

JF - Nature

IS - 7464

ER -

Richness of human gut microbiome correlates with metabolic markers

Abstract

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