Relative bioavailability of methadone hydrochloride administered in chewing gum and tablets

Lona Louring Christrup; H.R. Angelo; J. Bonde; F. Kristensen; S.N. Rasmussen

Relative bioavailability of methadone hydrochloride administered in chewing gum and tablets

Lona Louring Christrup, H.R. Angelo, J. Bonde, F. Kristensen, S.N. Rasmussen

11 Citations (Scopus)

Abstract

Methadone administered in chewing gum in doses of 16.7-22.6 mg to seven patients in a study using an open balanced cross-over design, was compared with 20 mg of methadone given perorally as tablets. There was no significant difference in the AUC/D obtained after administration of chewing gum and tablets (p>0.05). It is concluded that the chewing gum formulation should be considered for further testing with respect to suppression of abstinence syndrome in narcotic addicts.

Original language	English
Journal	Acta Pharmaceutica Nordica
Volume	2
Issue number	2
Pages (from-to)	83-88
Number of pages	6
ISSN	1100-1801
Publication status	Published - 1 Jan 1990

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abstract = "Methadone administered in chewing gum in doses of 16.7-22.6 mg to seven patients in a study using an open balanced cross-over design, was compared with 20 mg of methadone given perorally as tablets. There was no significant difference in the AUC/D obtained after administration of chewing gum and tablets (p>0.05). It is concluded that the chewing gum formulation should be considered for further testing with respect to suppression of abstinence syndrome in narcotic addicts.",

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AU - Christrup, Lona Louring

AU - Angelo, H.R.

AU - Bonde, J.

AU - Kristensen, F.

AU - Rasmussen, S.N.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Methadone administered in chewing gum in doses of 16.7-22.6 mg to seven patients in a study using an open balanced cross-over design, was compared with 20 mg of methadone given perorally as tablets. There was no significant difference in the AUC/D obtained after administration of chewing gum and tablets (p>0.05). It is concluded that the chewing gum formulation should be considered for further testing with respect to suppression of abstinence syndrome in narcotic addicts.

AB - Methadone administered in chewing gum in doses of 16.7-22.6 mg to seven patients in a study using an open balanced cross-over design, was compared with 20 mg of methadone given perorally as tablets. There was no significant difference in the AUC/D obtained after administration of chewing gum and tablets (p>0.05). It is concluded that the chewing gum formulation should be considered for further testing with respect to suppression of abstinence syndrome in narcotic addicts.

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M3 - Journal article

AN - SCOPUS:0025311038

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JO - Acta Pharmaceutica Nordica

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Relative bioavailability of methadone hydrochloride administered in chewing gum and tablets

Abstract

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