Relative bioavailability of methadone hydrochloride administered in chewing gum and tablets

TY - JOUR

T1 - Relative bioavailability of methadone hydrochloride administered in chewing gum and tablets

AU - Christrup, Lona Louring

AU - Angelo, H.R.

AU - Bonde, J.

AU - Kristensen, F.

AU - Rasmussen, S.N.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Methadone administered in chewing gum in doses of 16.7-22.6 mg to seven patients in a study using an open balanced cross-over design, was compared with 20 mg of methadone given perorally as tablets. There was no significant difference in the AUC/D obtained after administration of chewing gum and tablets (p>0.05). It is concluded that the chewing gum formulation should be considered for further testing with respect to suppression of abstinence syndrome in narcotic addicts.

AB - Methadone administered in chewing gum in doses of 16.7-22.6 mg to seven patients in a study using an open balanced cross-over design, was compared with 20 mg of methadone given perorally as tablets. There was no significant difference in the AUC/D obtained after administration of chewing gum and tablets (p>0.05). It is concluded that the chewing gum formulation should be considered for further testing with respect to suppression of abstinence syndrome in narcotic addicts.

UR - http://www.scopus.com/inward/record.url?scp=0025311038&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0025311038

SN - 1100-1801

VL - 2

SP - 83

EP - 88

JO - Acta Pharmaceutica Nordica

JF - Acta Pharmaceutica Nordica

IS - 2

ER -