Relative bioavailability in man of noscapine administered in lozenges and mixture

L.N. Jensen; Lona Louring Christrup; L. Jacobsen; J. Bonde; H. Bundgaard

Relative bioavailability in man of noscapine administered in lozenges and mixture

L.N. Jensen, Lona Louring Christrup, L. Jacobsen, J. Bonde, H. Bundgaard

6 Citations (Scopus)

Abstract

The bioavailability of noscapine base administered in lozenges in a dose of 100 mg to twelve healthy volunteers, in a study using an open balanced cross-over design, was compared with that of 100 mg of noscapine hydrochloride given perorally as a mixture. The bioavailability of noscapine after administration in lozenges was significantly higher than that after administration of the drug as a mixture. It is concluded that the lozenges containing noscapine base may be a valuable alternative to the conventional noscapine hydrochloride mixture.

Original language	English
Journal	Acta Pharmaceutica Nordica
Volume	4
Issue number	4
Pages (from-to)	309-312
Number of pages	4
ISSN	1100-1801
Publication status	Published - 1 Jan 1992

Cite this

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abstract = "The bioavailability of noscapine base administered in lozenges in a dose of 100 mg to twelve healthy volunteers, in a study using an open balanced cross-over design, was compared with that of 100 mg of noscapine hydrochloride given perorally as a mixture. The bioavailability of noscapine after administration in lozenges was significantly higher than that after administration of the drug as a mixture. It is concluded that the lozenges containing noscapine base may be a valuable alternative to the conventional noscapine hydrochloride mixture.",

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T1 - Relative bioavailability in man of noscapine administered in lozenges and mixture

AU - Jensen, L.N.

AU - Christrup, Lona Louring

AU - Jacobsen, L.

AU - Bonde, J.

AU - Bundgaard, H.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The bioavailability of noscapine base administered in lozenges in a dose of 100 mg to twelve healthy volunteers, in a study using an open balanced cross-over design, was compared with that of 100 mg of noscapine hydrochloride given perorally as a mixture. The bioavailability of noscapine after administration in lozenges was significantly higher than that after administration of the drug as a mixture. It is concluded that the lozenges containing noscapine base may be a valuable alternative to the conventional noscapine hydrochloride mixture.

AB - The bioavailability of noscapine base administered in lozenges in a dose of 100 mg to twelve healthy volunteers, in a study using an open balanced cross-over design, was compared with that of 100 mg of noscapine hydrochloride given perorally as a mixture. The bioavailability of noscapine after administration in lozenges was significantly higher than that after administration of the drug as a mixture. It is concluded that the lozenges containing noscapine base may be a valuable alternative to the conventional noscapine hydrochloride mixture.

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M3 - Journal article

AN - SCOPUS:0027051811

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SP - 309

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JO - Acta Pharmaceutica Nordica

JF - Acta Pharmaceutica Nordica

IS - 4

ER -

Relative bioavailability in man of noscapine administered in lozenges and mixture

Abstract

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