Relative bioavailability in man of noscapine administered in lozenges and mixture

TY - JOUR

T1 - Relative bioavailability in man of noscapine administered in lozenges and mixture

AU - Jensen, L.N.

AU - Christrup, Lona Louring

AU - Jacobsen, L.

AU - Bonde, J.

AU - Bundgaard, H.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The bioavailability of noscapine base administered in lozenges in a dose of 100 mg to twelve healthy volunteers, in a study using an open balanced cross-over design, was compared with that of 100 mg of noscapine hydrochloride given perorally as a mixture. The bioavailability of noscapine after administration in lozenges was significantly higher than that after administration of the drug as a mixture. It is concluded that the lozenges containing noscapine base may be a valuable alternative to the conventional noscapine hydrochloride mixture.

AB - The bioavailability of noscapine base administered in lozenges in a dose of 100 mg to twelve healthy volunteers, in a study using an open balanced cross-over design, was compared with that of 100 mg of noscapine hydrochloride given perorally as a mixture. The bioavailability of noscapine after administration in lozenges was significantly higher than that after administration of the drug as a mixture. It is concluded that the lozenges containing noscapine base may be a valuable alternative to the conventional noscapine hydrochloride mixture.

UR - http://www.scopus.com/inward/record.url?scp=0027051811&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0027051811

SN - 1100-1801

VL - 4

SP - 309

EP - 312

JO - Acta Pharmaceutica Nordica

JF - Acta Pharmaceutica Nordica

IS - 4

ER -