TY - JOUR
T1 - Regulation of vitamin C homeostasis during deficiency
AU - Lindblad, Maiken Marie
AU - Tveden-Nyborg, Pernille
AU - Lykkesfeldt, Jens
PY - 2013
Y1 - 2013
N2 - Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%-10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Particularly, little is known about how adaptive mechanisms during states of deficiency affect the overall regulation of vitamin C transport in the body. This review discusses mechanisms of vitamin C transport and potential means of regulation with special emphasis on capacity and functional properties, such as differences in the Km of vitamin C transporters in different target tissues, in some instances demonstrating a tissue-specific distribution.
AB - Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%-10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Particularly, little is known about how adaptive mechanisms during states of deficiency affect the overall regulation of vitamin C transport in the body. This review discusses mechanisms of vitamin C transport and potential means of regulation with special emphasis on capacity and functional properties, such as differences in the Km of vitamin C transporters in different target tissues, in some instances demonstrating a tissue-specific distribution.
KW - Faculty of Health and Medical Sciences
KW - vitamin C transport
KW - sodium-dependent vitamin C transporters
KW - SVCT1 and SVCT2
KW - glucose transporters (GLUTs)
KW - regulation of transport
U2 - 10.3390/nu5082860
DO - 10.3390/nu5082860
M3 - Journal article
SN - 2072-6643
VL - 5
SP - 2860
EP - 2879
JO - Nutrients
JF - Nutrients
IS - 8
ER -