Regulation of vitamin C homeostasis during deficiency

TY - JOUR

T1 - Regulation of vitamin C homeostasis during deficiency

AU - Lindblad, Maiken Marie

AU - Tveden-Nyborg, Pernille

AU - Lykkesfeldt, Jens

PY - 2013

Y1 - 2013

N2 - Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%-10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Particularly, little is known about how adaptive mechanisms during states of deficiency affect the overall regulation of vitamin C transport in the body. This review discusses mechanisms of vitamin C transport and potential means of regulation with special emphasis on capacity and functional properties, such as differences in the Km of vitamin C transporters in different target tissues, in some instances demonstrating a tissue-specific distribution.

AB - Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%-10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Particularly, little is known about how adaptive mechanisms during states of deficiency affect the overall regulation of vitamin C transport in the body. This review discusses mechanisms of vitamin C transport and potential means of regulation with special emphasis on capacity and functional properties, such as differences in the Km of vitamin C transporters in different target tissues, in some instances demonstrating a tissue-specific distribution.

KW - Faculty of Health and Medical Sciences

KW - vitamin C transport

KW - sodium-dependent vitamin C transporters

KW - SVCT1 and SVCT2

KW - glucose transporters (GLUTs)

KW - regulation of transport

U2 - 10.3390/nu5082860

DO - 10.3390/nu5082860

M3 - Journal article

SN - 2072-6643

VL - 5

SP - 2860

EP - 2879

JO - Nutrients

JF - Nutrients

IS - 8

ER -