Process development for spray drying of sticky pharmaceuticals; case study of mucoad-hesive nicotine microparticles for compressed medicated chewing gum

Camilla Sander; Henrik Stillhof  Nielsen; Susanne Roslev  Søgaard; Celina Støving Jensen; Mingshi Yang; Jette Jacobsen; Jukka Rantanen

doi:10.1016/j.ijpharm.2013.04.082

Process development for spray drying of sticky pharmaceuticals; case study of mucoad-hesive nicotine microparticles for compressed medicated chewing gum

Camilla Sander, Henrik Stillhof Nielsen, Susanne Roslev Søgaard, Celina Støving Jensen, Mingshi Yang, Jette Jacobsen, Jukka Rantanen

2 Citations (Scopus)

Abstract

Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.

Original language	English
Journal	International Journal of Pharmaceutics
Volume	452
Issue number	1-2
Pages (from-to)	434-437
ISSN	0378-5173
DOIs	https://doi.org/10.1016/j.ijpharm.2013.04.082
Publication status	Published - 2013

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Process development for spray drying of sticky pharmaceuticals; case study of mucoad-hesive nicotine microparticles for compressed medicated chewing gum. / Sander, Camilla; Nielsen, Henrik Stillhof ; Søgaard, Susanne Roslev et al.

In: International Journal of Pharmaceutics, Vol. 452, No. 1-2, 2013, p. 434-437.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Nielsen, Henrik Stillhof

AU - Søgaard, Susanne Roslev

AU - Jensen, Celina Støving

AU - Yang, Mingshi

AU - Jacobsen, Jette

AU - Rantanen, Jukka

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AB - Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.

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ER -

Process development for spray drying of sticky pharmaceuticals; case study of mucoad-hesive nicotine microparticles for compressed medicated chewing gum

Abstract

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