Process development for spray drying of sticky pharmaceuticals; case study of mucoad-hesive nicotine microparticles for compressed medicated chewing gum

Camilla Sander; Henrik Stillhof  Nielsen; Susanne Roslev  Søgaard; Celina Støving Jensen; Mingshi Yang; Jette Jacobsen; Jukka Rantanen

doi:10.1016/j.ijpharm.2013.04.082

Process development for spray drying of sticky pharmaceuticals; case study of mucoad-hesive nicotine microparticles for compressed medicated chewing gum

Camilla Sander, Henrik Stillhof Nielsen, Susanne Roslev Søgaard, Celina Støving Jensen, Mingshi Yang, Jette Jacobsen, Jukka Rantanen

2 Citationer (Scopus)

Abstract

Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.

Originalsprog	Engelsk
Tidsskrift	International Journal of Pharmaceutics
Vol/bind	452
Udgave nummer	1-2
Sider (fra-til)	434-437
ISSN	0378-5173
DOI	https://doi.org/10.1016/j.ijpharm.2013.04.082
Status	Udgivet - 2013

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10.1016/j.ijpharm.2013.04.082

Citationsformater

Process development for spray drying of sticky pharmaceuticals; case study of mucoad-hesive nicotine microparticles for compressed medicated chewing gum. / Sander, Camilla; Nielsen, Henrik Stillhof ; Søgaard, Susanne Roslev et al.

I: International Journal of Pharmaceutics, Bind 452, Nr. 1-2, 2013, s. 434-437.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.",

author = "Camilla Sander and Nielsen, {Henrik Stillhof} and S{\o}gaard, {Susanne Roslev} and Jensen, {Celina St{\o}ving} and Mingshi Yang and Jette Jacobsen and Jukka Rantanen",

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doi = "10.1016/j.ijpharm.2013.04.082",

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AU - Sander, Camilla

AU - Nielsen, Henrik Stillhof

AU - Søgaard, Susanne Roslev

AU - Jensen, Celina Støving

AU - Yang, Mingshi

AU - Jacobsen, Jette

AU - Rantanen, Jukka

PY - 2013

Y1 - 2013

N2 - Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.

AB - Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.

U2 - 10.1016/j.ijpharm.2013.04.082

DO - 10.1016/j.ijpharm.2013.04.082

M3 - Journal article

C2 - 23684657

SN - 0378-5173

VL - 452

SP - 434

EP - 437

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Process development for spray drying of sticky pharmaceuticals; case study of mucoad-hesive nicotine microparticles for compressed medicated chewing gum

Abstract

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