Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome

Kasper K Iversen; Ane S Teisner; Borge Teisner; Anette Kliem; Pia Thanning; Henrik Nielsen; Peter Clemmensen; Peer Grande; Kasper K Iversen; Ane S Teisner; Borge Teisner; Anette Kliem; Pia Thanning; Henrik Nielsen; Peter Clemmensen; Peer Grande

doi:10.1016/j.clinbiochem.2009.01.011

Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome

Kasper K Iversen, Ane S Teisner, Borge Teisner, Anette Kliem, Pia Thanning, Henrik Nielsen, Peter Clemmensen, Peer Grande, Kasper K Iversen, Ane S Teisner, Borge Teisner, Anette Kliem, Pia Thanning, Henrik Nielsen, Peter Clemmensen, Peer Grande

25 Citations (Scopus)

Abstract

OBJECTIVES: To describe the presence and time-related pattern of circulating pregnancy associated plasma protein A (PAPP-A) levels in patients with non ST-segment elevation acute coronary syndrome (NSTE-ACS). DESIGN AND METHODS: Consecutively admitted patients (N=573) with clinical signs of NSTE-ACS were included. Blood samples for analysis of PAPP-A were drawn at admission and every 6-8 h until levels of biomarkers of myocardial necrosis showed a consistent decrease. RESULTS: High-risk NSTE-ACS was diagnosed in 123 patients (23%). Significantly more patients with high-risk NSTE-ACS (63%) had detectable PAPP-A than did those with low-risk NSTE-ACS (49%) (P<0.001). PAPP-A concentrations were significantly associated with typical angina at admission, significant ST-depressions on the ECG, multivessel disease and presence of high-risk NSTE-ACS. CONCLUSION: PAPP-A seems to be a marker ischaemia both in patients with low- and high-risk NSTE-ACS, possibly due to the release of PAPP-A from the vulnerable plaque.

Original language	English
Journal	Clinical Biochemistry
Volume	42
Issue number	9
Pages (from-to)	828-34
Number of pages	6
ISSN	0009-9120
DOIs	https://doi.org/10.1016/j.clinbiochem.2009.01.011 https://doi.org/10.1016/j.clinbiochem.2009.01.011
Publication status	Published - 2009

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Iversen, K. K., Teisner, A. S., Teisner, B., Kliem, A., Thanning, P., Nielsen, H., Clemmensen, P., Grande, P., Iversen, K. K., Teisner, A. S., Teisner, B., Kliem, A., Thanning, P., Nielsen, H., Clemmensen, P., & Grande, P. (2009). Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome. Clinical Biochemistry, 42(9), 828-34. https://doi.org/10.1016/j.clinbiochem.2009.01.011, https://doi.org/10.1016/j.clinbiochem.2009.01.011

Iversen, KK, Teisner, AS, Teisner, B, Kliem, A, Thanning, P, Nielsen, H, Clemmensen, P, Grande, P, Iversen, KK, Teisner, AS, Teisner, B, Kliem, A, Thanning, P, Nielsen, H, Clemmensen, P & Grande, P 2009, 'Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome', Clinical Biochemistry, vol. 42, no. 9, pp. 828-34. https://doi.org/10.1016/j.clinbiochem.2009.01.011, https://doi.org/10.1016/j.clinbiochem.2009.01.011

@article{7475540064c711df928f000ea68e967b,

title = "Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome",

abstract = "OBJECTIVES: To describe the presence and time-related pattern of circulating pregnancy associated plasma protein A (PAPP-A) levels in patients with non ST-segment elevation acute coronary syndrome (NSTE-ACS). DESIGN AND METHODS: Consecutively admitted patients (N=573) with clinical signs of NSTE-ACS were included. Blood samples for analysis of PAPP-A were drawn at admission and every 6-8 h until levels of biomarkers of myocardial necrosis showed a consistent decrease. RESULTS: High-risk NSTE-ACS was diagnosed in 123 patients (23%). Significantly more patients with high-risk NSTE-ACS (63%) had detectable PAPP-A than did those with low-risk NSTE-ACS (49%) (P<0.001). PAPP-A concentrations were significantly associated with typical angina at admission, significant ST-depressions on the ECG, multivessel disease and presence of high-risk NSTE-ACS. CONCLUSION: PAPP-A seems to be a marker ischaemia both in patients with low- and high-risk NSTE-ACS, possibly due to the release of PAPP-A from the vulnerable plaque.",

author = "Iversen, {Kasper K} and Teisner, {Ane S} and Borge Teisner and Anette Kliem and Pia Thanning and Henrik Nielsen and Peter Clemmensen and Peer Grande and Iversen, {Kasper K} and Teisner, {Ane S} and Borge Teisner and Anette Kliem and Pia Thanning and Henrik Nielsen and Peter Clemmensen and Peer Grande",

note = "Keywords: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Electrocardiography; Female; Humans; Male; Middle Aged; Pregnancy-Associated Plasma Protein-A; Young Adult",

year = "2009",

doi = "10.1016/j.clinbiochem.2009.01.011",

language = "English",

volume = "42",

pages = "828--34",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier",

number = "9",

}

TY - JOUR

T1 - Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome

AU - Iversen, Kasper K

AU - Teisner, Ane S

AU - Teisner, Borge

AU - Kliem, Anette

AU - Thanning, Pia

AU - Nielsen, Henrik

AU - Clemmensen, Peter

AU - Grande, Peer

AU - Iversen, Kasper K

AU - Teisner, Ane S

AU - Teisner, Borge

AU - Kliem, Anette

AU - Thanning, Pia

AU - Nielsen, Henrik

AU - Clemmensen, Peter

AU - Grande, Peer

N1 - Keywords: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Electrocardiography; Female; Humans; Male; Middle Aged; Pregnancy-Associated Plasma Protein-A; Young Adult

PY - 2009

Y1 - 2009

N2 - OBJECTIVES: To describe the presence and time-related pattern of circulating pregnancy associated plasma protein A (PAPP-A) levels in patients with non ST-segment elevation acute coronary syndrome (NSTE-ACS). DESIGN AND METHODS: Consecutively admitted patients (N=573) with clinical signs of NSTE-ACS were included. Blood samples for analysis of PAPP-A were drawn at admission and every 6-8 h until levels of biomarkers of myocardial necrosis showed a consistent decrease. RESULTS: High-risk NSTE-ACS was diagnosed in 123 patients (23%). Significantly more patients with high-risk NSTE-ACS (63%) had detectable PAPP-A than did those with low-risk NSTE-ACS (49%) (P<0.001). PAPP-A concentrations were significantly associated with typical angina at admission, significant ST-depressions on the ECG, multivessel disease and presence of high-risk NSTE-ACS. CONCLUSION: PAPP-A seems to be a marker ischaemia both in patients with low- and high-risk NSTE-ACS, possibly due to the release of PAPP-A from the vulnerable plaque.

AB - OBJECTIVES: To describe the presence and time-related pattern of circulating pregnancy associated plasma protein A (PAPP-A) levels in patients with non ST-segment elevation acute coronary syndrome (NSTE-ACS). DESIGN AND METHODS: Consecutively admitted patients (N=573) with clinical signs of NSTE-ACS were included. Blood samples for analysis of PAPP-A were drawn at admission and every 6-8 h until levels of biomarkers of myocardial necrosis showed a consistent decrease. RESULTS: High-risk NSTE-ACS was diagnosed in 123 patients (23%). Significantly more patients with high-risk NSTE-ACS (63%) had detectable PAPP-A than did those with low-risk NSTE-ACS (49%) (P<0.001). PAPP-A concentrations were significantly associated with typical angina at admission, significant ST-depressions on the ECG, multivessel disease and presence of high-risk NSTE-ACS. CONCLUSION: PAPP-A seems to be a marker ischaemia both in patients with low- and high-risk NSTE-ACS, possibly due to the release of PAPP-A from the vulnerable plaque.

U2 - 10.1016/j.clinbiochem.2009.01.011

DO - 10.1016/j.clinbiochem.2009.01.011

M3 - Journal article

C2 - 19318028

SN - 0009-9120

VL - 42

SP - 828

EP - 834

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 9

ER -

Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome

Abstract

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