Research output per year
Research output per year
Personal profile
Primary fields of research
RNA biology with emphasis on catalytic RNA and epitranscriptomics
Current research
- The flexibility and evolutionary adaptability of RNA-guided nucleotide modifications
- Specialized ribosomes (including cancer ribosomes)
- The role of helicases in ribosome biogenesis
- New RNA cap structures
- The lariat capping ribozyme
- Characterization of the circularization pathway in group I introns
CV
Name: Henrik Nielsen Born: November 25, 1955 in Copenhagen, Denmark
Address: Stenløsevej 18, 2700 Brønshøj, Denmark
education/degrees
• Cand. scient. (Masters) in Molecular Biology, University of Copenhagen (1983). • Lic. scient. (PhD) in Molecular Biology, University of Copenhagen (1990).
honors
"Teacher of the year 1998" at the Health Science Faculty, University of Copenhagen.
positions/fellowships:
| Aug. 1984 - Febr. 1991 | University fellowships and fellowship from the Danish Research at Dept. of Biochemistry,Univ.of Copenhagen. |
| Aug. 1988 - Nov. 1988 | Scientific adviser on TV-production ("Den Nye Arv"), DR-TV and Univ. of Copenhagen. |
| Febr. 1991 - Jan. 1995 | Assistant Professor, Dept. of Biochemistry,Univ.of Copenhagen. |
| Febr. 1995 – Sept. 2009 | Associate Professor, Dept. of Biochemistry (now Dept. of Cellular and Molecular Medicine),Univ.ofCopenhagen. |
| July 2004 - June 2008 | Associate Professor 2, Dept. of Molecular Biotechnology, Univ. of Tromsø, Norway |
| October 2009 - | Professor MSO, Dept. of Cellular and Molecular Medicine, Univ. of Copenhagen. |
| November 2009 - | Professor 2, Dept. of Molecular Pathology,Univ. of Tromsø,Norway |
Key research topics: RNA biology with emphasis on ribozymes, RNA splicing and small non-coding RNA molecules. Lupus nephritis.
Present networks: Centre for non-coding RNA in Technology and Health (a large international centre funded by the Danish Strategic Research Council) as work package manager, member of NORFA network on non-coding RNA and COST network on non-mendelian inheritance.
Main collaborators: Dr. Benoit Masquida and Prof. Eric Westhof, CNRS, Strasbourg; Prof. Steinar Johansen and Prof. Ole Petter Rekvig, Univ. of Tromsø; Prof. Søren Jakobsen, Rigshospitalet, Copenhagen; Prof. Jan Gorodkin, Univ. of Copenhagen; Prof. Torben Heick Jensen, University of Aarhus; Assoc. Prof. Finn Kirpekar, University of Southern Denmark; Senior scientist Knud Josefsen, The Bartholin Institute, Dr. Martin Pospisek, Charles University, Prague.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- RNA biology
- Functional genomics
- Ribozymes
- Lariat capping
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Collaborations and top research areas from the last five years
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Developmental changes of rRNA ribose methylations in the mouse
Hebras, J., Krogh, N., Marty, V., Nielsen, H. & Cavaillé, J., 2 Jan 2020, In: RNA Biology. p. 1-15 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Risk factors and prognosis of seizures in adults with community-acquired bacterial meningitis in Denmark: observational cohort studies
DASGIB study group, 1 Jul 2019, In: BMJ Open. 9, 9 p., e030263.Research output: Contribution to journal › Journal article › Research › peer-review
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Sequencing-based methods for detection and quantitation of ribose methylations in RNA
Krogh, N. & Nielsen, H., 1 Mar 2019, In: Methods.Research output: Contribution to journal › Journal article › Research › peer-review
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Knock-Down of a Novel snoRNA in Tetrahymena Reveals a Dual Role in 5.8S rRNA Processing and Generation of a 26S rRNA Fragment
Andersen, K. L. & Nielsen, H., Dec 2018, In: Biomolecules. 8, 4, 19 p., 128.Research output: Contribution to journal › Journal article › Research › peer-review
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Positioning Europe for the EPITRANSCRIPTOMICS challenge
Jantsch, M. F., Quattrone, A., O'Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., Ohman, M., Ameres, S., Willems, L., Fuks, F., Oulas, A., Vanacova, S., Nielsen, H., Bousquet-Antonelli, C., Motorin, Y., Roignant, J-Y., Balatsos, N., Dinnyes, A., Baranov, P., Kelly, V., & 40 others, 3 Jun 2018, In: RNA Biology. 15, 6, p. 829-831 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle
Iyer-Bierhoff, A., Krogh, N., Tessarz, P., Ruppert, T., Nielsen, H. & Grummt, I., 11 Dec 2018, In: Cell Reports. 25, 11, p. 2946-2954Research output: Contribution to journal › Journal article › Research › peer-review
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Bypassing rRNA methylation by RsmA/Dim1during ribosome maturation in the hyperthermophilic archaeon Nanoarchaeum equitans
Seistrup, K. H., Rose, S., Birkedal, U., Nielsen, H., Huber, H. & Douthwaite, S., 28 Feb 2017, In: Nucleic Acids Research. 45, 4, p. 2007-2015 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lariat capping as a tool to manipulate the 5' end of individual yeast mRNA species in vivo
Krogh, N., Pietschmann, M., Schmid, M., Jensen, T. H. & Nielsen, H., May 2017, In: R N A. 23, 5, p. 683-695 13 p.Research output: Contribution to journal › Journal article › Research › peer-review