@article{7475540064c711df928f000ea68e967b,
title = "Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome",
abstract = "OBJECTIVES: To describe the presence and time-related pattern of circulating pregnancy associated plasma protein A (PAPP-A) levels in patients with non ST-segment elevation acute coronary syndrome (NSTE-ACS). DESIGN AND METHODS: Consecutively admitted patients (N=573) with clinical signs of NSTE-ACS were included. Blood samples for analysis of PAPP-A were drawn at admission and every 6-8 h until levels of biomarkers of myocardial necrosis showed a consistent decrease. RESULTS: High-risk NSTE-ACS was diagnosed in 123 patients (23%). Significantly more patients with high-risk NSTE-ACS (63%) had detectable PAPP-A than did those with low-risk NSTE-ACS (49%) (P<0.001). PAPP-A concentrations were significantly associated with typical angina at admission, significant ST-depressions on the ECG, multivessel disease and presence of high-risk NSTE-ACS. CONCLUSION: PAPP-A seems to be a marker ischaemia both in patients with low- and high-risk NSTE-ACS, possibly due to the release of PAPP-A from the vulnerable plaque.",
author = "Iversen, {Kasper K} and Teisner, {Ane S} and Borge Teisner and Anette Kliem and Pia Thanning and Henrik Nielsen and Peter Clemmensen and Peer Grande and Iversen, {Kasper K} and Teisner, {Ane S} and Borge Teisner and Anette Kliem and Pia Thanning and Henrik Nielsen and Peter Clemmensen and Peer Grande",
note = "Keywords: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Electrocardiography; Female; Humans; Male; Middle Aged; Pregnancy-Associated Plasma Protein-A; Young Adult",
year = "2009",
doi = "10.1016/j.clinbiochem.2009.01.011",
language = "English",
volume = "42",
pages = "828--34",
journal = "Clinical Biochemistry",
issn = "0009-9120",
publisher = "Elsevier",
number = "9",
}