Peptide nucleic acids and the origin of life

Peter E. Nielsen

doi:10.1002/cbdv.200790166

Peptide nucleic acids and the origin of life

Transcription, RNA, and Gene Medicine Program

Abstract

The possibilities of pseudo-peptide-DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the possibilities of template-directed PNA chemical replication and ligation. In particular, the merits of an achiral prebiotic genetic material is discussed.

Original language	English
Journal	Chemistry & Biodiversity
Volume	4
Issue number	9
Pages (from-to)	1996-2002
Number of pages	7
ISSN	1612-1872
DOIs	https://doi.org/10.1002/cbdv.200790166
Publication status	Published - Sept 2007

Keywords

Evolution, Molecular
Nucleic Acid Conformation
Origin of Life
Peptide Nucleic Acids/chemistry
Protein Conformation

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10.1002/cbdv.200790166

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AB - The possibilities of pseudo-peptide-DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the possibilities of template-directed PNA chemical replication and ligation. In particular, the merits of an achiral prebiotic genetic material is discussed.

KW - Evolution, Molecular

KW - Nucleic Acid Conformation

KW - Origin of Life

KW - Peptide Nucleic Acids/chemistry

KW - Protein Conformation

U2 - 10.1002/cbdv.200790166

DO - 10.1002/cbdv.200790166

M3 - Review

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VL - 4

SP - 1996

EP - 2002

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

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ER -

Peptide nucleic acids and the origin of life

Abstract

Keywords

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