Peptide nucleic acids and the origin of life

Peter E. Nielsen

doi:10.1002/cbdv.200790166

Peptide nucleic acids and the origin of life

Transcription, RNA, and Gene Medicine Program

Abstract

The possibilities of pseudo-peptide-DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the possibilities of template-directed PNA chemical replication and ligation. In particular, the merits of an achiral prebiotic genetic material is discussed.

Originalsprog	Engelsk
Tidsskrift	Chemistry & Biodiversity
Vol/bind	4
Udgave nummer	9
Sider (fra-til)	1996-2002
Antal sider	7
ISSN	1612-1872
DOI	https://doi.org/10.1002/cbdv.200790166
Status	Udgivet - sep. 2007

Adgang til dokumentet

10.1002/cbdv.200790166

Citationsformater

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title = "Peptide nucleic acids and the origin of life",

abstract = "The possibilities of pseudo-peptide-DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the possibilities of template-directed PNA chemical replication and ligation. In particular, the merits of an achiral prebiotic genetic material is discussed.",

keywords = "Evolution, Molecular, Nucleic Acid Conformation, Origin of Life, Peptide Nucleic Acids/chemistry, Protein Conformation",

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N2 - The possibilities of pseudo-peptide-DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the possibilities of template-directed PNA chemical replication and ligation. In particular, the merits of an achiral prebiotic genetic material is discussed.

AB - The possibilities of pseudo-peptide-DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the possibilities of template-directed PNA chemical replication and ligation. In particular, the merits of an achiral prebiotic genetic material is discussed.

KW - Evolution, Molecular

KW - Nucleic Acid Conformation

KW - Origin of Life

KW - Peptide Nucleic Acids/chemistry

KW - Protein Conformation

U2 - 10.1002/cbdv.200790166

DO - 10.1002/cbdv.200790166

M3 - Review

C2 - 17886856

SN - 1612-1872

VL - 4

SP - 1996

EP - 2002

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 9

ER -

Peptide nucleic acids and the origin of life

Abstract

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