Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial

Michael Tvilling Madsen; Bülent Kücükakin; Jens Lykkesfeldt; Jacob Rosenberg; Ismail Gögenur

doi:10.1097/SLE.0b013e31824ddda9

Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial

Michael Tvilling Madsen, Bülent Kücükakin, Jens Lykkesfeldt, Jacob Rosenberg, Ismail Gögenur

Lifepharm

3 Citations (Scopus)

Abstract

Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality. Oxidative stress is a part of the surgical stress response. Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery. Nineteen patients scheduled for sigmoid resection were randomly allocated to open or laparoscopic sigmoid resection in a double-blind, prospective clinical trial. Three biochemical markers of oxidative stress (malondialdehyde, ascorbic acid, and dehydroascorbic acid) were measured at 6 different time points (preoperatively, 1 h, 6 h, 24 h, 48 h, and 72 h postoperatively). There were no statistical significant differences between laparoscopic and open surgery for any of the 3 oxidative stress parameters. Malondialdehyde was reduced 1 hour postoperatively (P

Original language	English
Journal	Surgical Laparoscopy, Endoscopy and Percutaneous Techniques
Volume	22
Issue number	3
Pages (from-to)	215-219
Number of pages	5
ISSN	1530-4515
DOIs	https://doi.org/10.1097/SLE.0b013e31824ddda9
Publication status	Published - Jun 2012

Keywords

Former LIFE faculty

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10.1097/SLE.0b013e31824ddda9

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Oxidative stress response after laparoscopic versus conventional sigmoid resection : a randomized, double-blind clinical trial. / Madsen, Michael Tvilling; Kücükakin, Bülent; Lykkesfeldt, Jens et al.

In: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques, Vol. 22, No. 3, 06.2012, p. 215-219.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality. Oxidative stress is a part of the surgical stress response. Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery. Nineteen patients scheduled for sigmoid resection were randomly allocated to open or laparoscopic sigmoid resection in a double-blind, prospective clinical trial. Three biochemical markers of oxidative stress (malondialdehyde, ascorbic acid, and dehydroascorbic acid) were measured at 6 different time points (preoperatively, 1 h, 6 h, 24 h, 48 h, and 72 h postoperatively). There were no statistical significant differences between laparoscopic and open surgery for any of the 3 oxidative stress parameters. Malondialdehyde was reduced 1 hour postoperatively (P",

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AU - Rosenberg, Jacob

AU - Gögenur, Ismail

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Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial

Abstract

Keywords

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