Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial

TY - JOUR

T1 - Oxidative stress response after laparoscopic versus conventional sigmoid resection

T2 - a randomized, double-blind clinical trial

AU - Madsen, Michael Tvilling

AU - Kücükakin, Bülent

AU - Lykkesfeldt, Jens

AU - Rosenberg, Jacob

AU - Gögenur, Ismail

PY - 2012/6

Y1 - 2012/6

N2 - Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality. Oxidative stress is a part of the surgical stress response. Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery. Nineteen patients scheduled for sigmoid resection were randomly allocated to open or laparoscopic sigmoid resection in a double-blind, prospective clinical trial. Three biochemical markers of oxidative stress (malondialdehyde, ascorbic acid, and dehydroascorbic acid) were measured at 6 different time points (preoperatively, 1 h, 6 h, 24 h, 48 h, and 72 h postoperatively). There were no statistical significant differences between laparoscopic and open surgery for any of the 3 oxidative stress parameters. Malondialdehyde was reduced 1 hour postoperatively (P

AB - Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality. Oxidative stress is a part of the surgical stress response. Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery. Nineteen patients scheduled for sigmoid resection were randomly allocated to open or laparoscopic sigmoid resection in a double-blind, prospective clinical trial. Three biochemical markers of oxidative stress (malondialdehyde, ascorbic acid, and dehydroascorbic acid) were measured at 6 different time points (preoperatively, 1 h, 6 h, 24 h, 48 h, and 72 h postoperatively). There were no statistical significant differences between laparoscopic and open surgery for any of the 3 oxidative stress parameters. Malondialdehyde was reduced 1 hour postoperatively (P

KW - Former LIFE faculty

KW - sigmoid resection

KW - oxidative stress response

KW - lipid peroxidation

KW - antioxidants

U2 - 10.1097/SLE.0b013e31824ddda9

DO - 10.1097/SLE.0b013e31824ddda9

M3 - Journal article

C2 - 22678316

SN - 1530-4515

VL - 22

SP - 215

EP - 219

JO - Surgical Laparoscopy and Endoscopy

JF - Surgical Laparoscopy and Endoscopy

IS - 3

ER -