Origin of introns by 'intronization' of exonic sequences.

TY - JOUR

T1 - Origin of introns by 'intronization' of exonic sequences.

AU - Irimia, Manuel

AU - Rukov, Jakob Lewin

AU - Penny, David

AU - Vinther, Jeppe

AU - Garcia-Fernandez, Jordi

AU - Roy, Scott William

PY - 2008

Y1 - 2008

N2 - The mechanisms of spliceosomal intron creation have proved elusive. Here we describe a new mechanism: the recruitment of internal exonic sequences ('intronization') in Caenorhabditis species. The numbers of intronization events and introns gained by other mechanisms are similar, suggesting that intronization significantly contributes to recent intron creation in nematodes. Intronization is more common than the reverse process, loss of splicing of retained introns. Finally, these findings link alternative splicing with modern intron creation.

AB - The mechanisms of spliceosomal intron creation have proved elusive. Here we describe a new mechanism: the recruitment of internal exonic sequences ('intronization') in Caenorhabditis species. The numbers of intronization events and introns gained by other mechanisms are similar, suggesting that intronization significantly contributes to recent intron creation in nematodes. Intronization is more common than the reverse process, loss of splicing of retained introns. Finally, these findings link alternative splicing with modern intron creation.

U2 - 10.1016/j.tig.2008.05.007

DO - 10.1016/j.tig.2008.05.007

M3 - Journal article

C2 - 18597887

SN - 0168-9525

JO - Trends in Genetics

JF - Trends in Genetics

ER -