No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample

Andrés Ingason; Karen Søeby; Sally Timm; August G Wang; Klaus D Jakobsen; Anders Fink-Jensen; Ralf Peter Arnfred Hemmingsen; Henrik Berg Rasmussen; Thomas Werge

doi:http://dx.doi.org/10.1016/j.schres.2005.12.850

No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample

Andrés Ingason, Karen Søeby, Sally Timm, August G Wang, Klaus D Jakobsen, Anders Fink-Jensen, Ralf Peter Arnfred Hemmingsen, Henrik Berg Rasmussen, Thomas Werge

20 Citations (Scopus)

Abstract

Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.

Original language	English
Journal	Schizophrenia Research
Volume	83
Issue number	1
Pages (from-to)	1-5
Number of pages	5
ISSN	0920-9964
DOIs	https://doi.org/10.1016/j.schres.2005.12.850
Publication status	Published - 2006

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title = "No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample",

abstract = "Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.",

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T1 - No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample

AU - Ingason, Andrés

AU - Søeby, Karen

AU - Timm, Sally

AU - Wang, August G

AU - Jakobsen, Klaus D

AU - Fink-Jensen, Anders

AU - Hemmingsen, Ralf Peter Arnfred

AU - Berg Rasmussen, Henrik

AU - Werge, Thomas

PY - 2006

Y1 - 2006

N2 - Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.

AB - Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.

U2 - http://dx.doi.org/10.1016/j.schres.2005.12.850

DO - http://dx.doi.org/10.1016/j.schres.2005.12.850

M3 - Journal article

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SP - 1

EP - 5

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1

ER -

No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample

Abstract

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