TY - JOUR
T1 - No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample
AU - Ingason, Andrés
AU - Søeby, Karen
AU - Timm, Sally
AU - Wang, August G
AU - Jakobsen, Klaus D
AU - Fink-Jensen, Anders
AU - Hemmingsen, Ralf Peter Arnfred
AU - Berg Rasmussen, Henrik
AU - Werge, Thomas
PY - 2006
Y1 - 2006
N2 - Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.
AB - Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.
U2 - 10.1016/j.schres.2005.12.850
DO - 10.1016/j.schres.2005.12.850
M3 - Journal article
SN - 0920-9964
VL - 83
SP - 1
EP - 5
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1
ER -