Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling

Michael J Bailey; Steven L Coon; John David Carter; Ann Humphries; Jong-So Kim; Qiong Shi; Pascaline Gaildrat; Fabrice Morin; Surajit Ganguly; John B Hogenesch; Joan L Weller; Martin F Rath; Morten Møller; Ruben Baler; David Sugden; Zoila G Rangel; Peter J Munson; David C Klein

doi:10.1074/jbc.M808394200

Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling

Michael J Bailey, Steven L Coon, John David Carter, Ann Humphries, Jong-So Kim, Qiong Shi, Pascaline Gaildrat, Fabrice Morin, Surajit Ganguly, John B Hogenesch, Joan L Weller, Martin F Rath, Morten Møller, Ruben Baler, David Sugden, Zoila G Rangel, Peter J Munson, David C Klein

111 Citations (Scopus)

Abstract

The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip(R) technology to obtain a more complete description of pineal cell biology. The effort revealed that 604 genes (1,268 probe sets) with Entrez Gene identifiers are differentially expressed greater than 2-fold between midnight and mid-day (false discovery rate

Original language	English
Journal	Journal of Biological Chemistry
Volume	284
Issue number	12
Pages (from-to)	7606-22
Number of pages	17
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M808394200
Publication status	Published - 2009

Keywords

Animals
Circadian Rhythm
Cyclic AMP
Gene Expression Profiling
Gene Expression Regulation
Norepinephrine
Oligonucleotide Array Sequence Analysis
Organ Specificity
Pineal Gland
Rats
Rats, Sprague-Dawley
Retina

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Bailey, M. J., Coon, S. L., Carter, J. D., Humphries, A., Kim, J-S., Shi, Q., Gaildrat, P., Morin, F., Ganguly, S., Hogenesch, J. B., Weller, J. L., Rath, M. F., Møller, M., Baler, R., Sugden, D., Rangel, Z. G., Munson, P. J., & Klein, D. C. (2009). Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. Journal of Biological Chemistry, 284(12), 7606-22. https://doi.org/10.1074/jbc.M808394200

Bailey, MJ, Coon, SL, Carter, JD, Humphries, A, Kim, J-S, Shi, Q, Gaildrat, P, Morin, F, Ganguly, S, Hogenesch, JB, Weller, JL, Rath, MF , Møller, M, Baler, R, Sugden, D, Rangel, ZG, Munson, PJ & Klein, DC 2009, 'Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling', Journal of Biological Chemistry, vol. 284, no. 12, pp. 7606-22. https://doi.org/10.1074/jbc.M808394200

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abstract = "The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip(R) technology to obtain a more complete description of pineal cell biology. The effort revealed that 604 genes (1,268 probe sets) with Entrez Gene identifiers are differentially expressed greater than 2-fold between midnight and mid-day (false discovery rate ",

keywords = "Animals, Circadian Rhythm, Cyclic AMP, Gene Expression Profiling, Gene Expression Regulation, Norepinephrine, Oligonucleotide Array Sequence Analysis, Organ Specificity, Pineal Gland, Rats, Rats, Sprague-Dawley, Retina, circadian rhythms, gene exression, pieneal",

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AU - Bailey, Michael J

AU - Coon, Steven L

AU - Carter, John David

AU - Humphries, Ann

AU - Kim, Jong-So

AU - Shi, Qiong

AU - Gaildrat, Pascaline

AU - Morin, Fabrice

AU - Ganguly, Surajit

AU - Hogenesch, John B

AU - Weller, Joan L

AU - Rath, Martin F

AU - Møller, Morten

AU - Baler, Ruben

AU - Sugden, David

AU - Rangel, Zoila G

AU - Munson, Peter J

AU - Klein, David C

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N2 - The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip(R) technology to obtain a more complete description of pineal cell biology. The effort revealed that 604 genes (1,268 probe sets) with Entrez Gene identifiers are differentially expressed greater than 2-fold between midnight and mid-day (false discovery rate

AB - The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip(R) technology to obtain a more complete description of pineal cell biology. The effort revealed that 604 genes (1,268 probe sets) with Entrez Gene identifiers are differentially expressed greater than 2-fold between midnight and mid-day (false discovery rate

KW - Animals

KW - Circadian Rhythm

KW - Cyclic AMP

KW - Gene Expression Profiling

KW - Gene Expression Regulation

KW - Norepinephrine

KW - Oligonucleotide Array Sequence Analysis

KW - Organ Specificity

KW - Pineal Gland

KW - Rats

KW - Rats, Sprague-Dawley

KW - Retina

KW - circadian rhythms, gene exression, pieneal

U2 - 10.1074/jbc.M808394200

DO - 10.1074/jbc.M808394200

M3 - Journal article

C2 - 19103603

SN - 0021-9258

VL - 284

SP - 7606

EP - 7622

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 12

ER -

Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling

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Keywords

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