Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling

Michael J Bailey, Steven L Coon, John David Carter, Ann Humphries, Jong-So Kim, Qiong Shi, Pascaline Gaildrat, Fabrice Morin, Surajit Ganguly, John B Hogenesch, Joan L Weller, Martin F Rath, Morten Møller, Ruben Baler, David Sugden, Zoila G Rangel, Peter J Munson, David C Klein

111 Citationer (Scopus)

Abstract

The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip(R) technology to obtain a more complete description of pineal cell biology. The effort revealed that 604 genes (1,268 probe sets) with Entrez Gene identifiers are differentially expressed greater than 2-fold between midnight and mid-day (false discovery rate
OriginalsprogEngelsk
TidsskriftJournal of Biological Chemistry
Vol/bind284
Udgave nummer12
Sider (fra-til)7606-22
Antal sider17
ISSN0021-9258
DOI
StatusUdgivet - 2009

Emneord

  • circadian rhythms, gene exression, pieneal

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