Molecular profiling of intrahepatic cholangiocarcinoma: the search for new therapeutic targets

Douglas V N P Oliveira; Shanshan Zhang; Xin Chen; Diego F Calvisi; Jesper B Andersen

doi:10.1080/17474124.2017.1292127

Molecular profiling of intrahepatic cholangiocarcinoma: the search for new therapeutic targets

Douglas V N P Oliveira, Shanshan Zhang, Xin Chen, Diego F Calvisi, Jesper B Andersen

10 Citations (Scopus)

Abstract

INTRODUCTION: Intrahepatic cholangiocarcinoma (iCCA) is the second most frequent primary tumor of the liver and a highly lethal disease. Therapeutic options for advanced iCCA are limited and ineffective due to the largely incomplete understanding of the molecular pathogenesis of this deadly tumor. Areas covered: The present review article outlines the main studies and resulting discoveries on the molecular profiling of iCCA, with a special emphasis on the different techniques used for this purpose, the diagnostic and prognostic markers identified, as well as the genes and pathways that could be potentially targeted with innovative therapies. Expert commentary: Molecular profiling has led to the identification of distinct iCCA subtypes, characterized by peculiar genetic alterations and transcriptomic features. Targeted therapies against some of the identified genes are ongoing and hold great promise to improve the prognosis of iCCA patients.

Original language	English
Journal	Expert Review of Gastroenterology & Hepatology
Volume	11
Issue number	4
Pages (from-to)	349-356
Number of pages	8
ISSN	1747-4124
DOIs	https://doi.org/10.1080/17474124.2017.1292127
Publication status	Published - 3 Apr 2017

Access to Document

10.1080/17474124.2017.1292127

Cite this

@article{2ee2e3e2a5394d058e2ae1a0eae9c04b,

title = "Molecular profiling of intrahepatic cholangiocarcinoma: the search for new therapeutic targets",

abstract = "INTRODUCTION: Intrahepatic cholangiocarcinoma (iCCA) is the second most frequent primary tumor of the liver and a highly lethal disease. Therapeutic options for advanced iCCA are limited and ineffective due to the largely incomplete understanding of the molecular pathogenesis of this deadly tumor. Areas covered: The present review article outlines the main studies and resulting discoveries on the molecular profiling of iCCA, with a special emphasis on the different techniques used for this purpose, the diagnostic and prognostic markers identified, as well as the genes and pathways that could be potentially targeted with innovative therapies. Expert commentary: Molecular profiling has led to the identification of distinct iCCA subtypes, characterized by peculiar genetic alterations and transcriptomic features. Targeted therapies against some of the identified genes are ongoing and hold great promise to improve the prognosis of iCCA patients.",

author = "Oliveira, {Douglas V N P} and Shanshan Zhang and Xin Chen and Calvisi, {Diego F} and Andersen, {Jesper B}",

year = "2017",

month = apr,

day = "3",

doi = "10.1080/17474124.2017.1292127",

language = "English",

volume = "11",

pages = "349--356",

journal = "Expert Review of Gastroenterology & Hepatology",

issn = "1747-4124",

publisher = "Taylor & Francis",

number = "4",

}

TY - JOUR

T1 - Molecular profiling of intrahepatic cholangiocarcinoma

T2 - the search for new therapeutic targets

AU - Oliveira, Douglas V N P

AU - Zhang, Shanshan

AU - Chen, Xin

AU - Calvisi, Diego F

AU - Andersen, Jesper B

PY - 2017/4/3

Y1 - 2017/4/3

N2 - INTRODUCTION: Intrahepatic cholangiocarcinoma (iCCA) is the second most frequent primary tumor of the liver and a highly lethal disease. Therapeutic options for advanced iCCA are limited and ineffective due to the largely incomplete understanding of the molecular pathogenesis of this deadly tumor. Areas covered: The present review article outlines the main studies and resulting discoveries on the molecular profiling of iCCA, with a special emphasis on the different techniques used for this purpose, the diagnostic and prognostic markers identified, as well as the genes and pathways that could be potentially targeted with innovative therapies. Expert commentary: Molecular profiling has led to the identification of distinct iCCA subtypes, characterized by peculiar genetic alterations and transcriptomic features. Targeted therapies against some of the identified genes are ongoing and hold great promise to improve the prognosis of iCCA patients.

AB - INTRODUCTION: Intrahepatic cholangiocarcinoma (iCCA) is the second most frequent primary tumor of the liver and a highly lethal disease. Therapeutic options for advanced iCCA are limited and ineffective due to the largely incomplete understanding of the molecular pathogenesis of this deadly tumor. Areas covered: The present review article outlines the main studies and resulting discoveries on the molecular profiling of iCCA, with a special emphasis on the different techniques used for this purpose, the diagnostic and prognostic markers identified, as well as the genes and pathways that could be potentially targeted with innovative therapies. Expert commentary: Molecular profiling has led to the identification of distinct iCCA subtypes, characterized by peculiar genetic alterations and transcriptomic features. Targeted therapies against some of the identified genes are ongoing and hold great promise to improve the prognosis of iCCA patients.

U2 - 10.1080/17474124.2017.1292127

DO - 10.1080/17474124.2017.1292127

M3 - Review

C2 - 28162004

SN - 1747-4124

VL - 11

SP - 349

EP - 356

JO - Expert Review of Gastroenterology & Hepatology

JF - Expert Review of Gastroenterology & Hepatology

IS - 4

ER -

Molecular profiling of intrahepatic cholangiocarcinoma: the search for new therapeutic targets

Abstract

Access to Document

Fingerprint

Cite this